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Anti-inflammatory activity and molecular mechanism of Oolong tea theasinensin

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Food & Function Vol - 5 Issue - 7

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Anti-inflammatory activity and molecular mechanism of Oolong tea theasinensin

Content Provider	Royal Society of Chemistry (RSC)
Author	Sakao, Kozue Hisanaga, Ayami Hashimoto, Fumio Sogo, Takayuki Ishida, Hisako Kumamoto, Takuma Hou, De-Xing
Copyright Year	2014
Abstract	Oolong tea theasinensins are a group of tea polyphenols different from green tea catechins and black tea theaflavins, and they are considered as bioactive compounds in Oolong tea. In the present study, based on the properties of theasinensin and information about inflammatory processes, we investigated the anti-inflammatory activity and molecular mechanisms of theasinensin A (TSA) in both cell and animal models. In the cell model, TSA reduced the levels of pro-inflammatory mediators including inducible nitric oxide synthase (iNOS), nitric oxide (NO), interleukin-12 (IL-12) (p70), tumor necrosis factor alpha (TNF-α), and monocyte chemotactic protein-1 (MCP-1) induced by lipopolysaccharide (LPS). Cellular signaling analysis revealed that TSA downregulated MAPK/ERK kinase (MEK)-extracellular signal-regulated kinase (ERK) signaling. Pull-down assay and affinity data revealed that TSA might directly bind to MEK-ERK for the inhibitory action. In the animal model, TSA suppressed the production of IL-12 (p70), TNF-α, and MCP-1 and attenuated mouse paw edema induced by LPS.
Starting Page	1891
Ending Page	1897
Page Count	7
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	5
Issue Number	8
Journal	Food & Function
DOI	10.1039/c4fo00152d
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	TSA Oolong Tea Green tea Black tea Nitric oxide synthase Nitric oxide Interleukin 12 Tumor necrosis factor alpha Monocyte Protein Lipopolysaccharide MAPK\/ERK pathway Kinase Extracellular signal\u2013regulated kinases Mitogen-activated protein kinase Model organism Mouse Edema Honduran lempira
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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Anti-inflammatory activity and molecular mechanism of Oolong tea theasinensin

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