NDLI: The anti-tumor efficiency of pterostilbene is promoted with a combined treatment of Fas signaling or autophagy inhibitors in triple negative breast cancer cells

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The anti-tumor efficiency of pterostilbene is promoted with a combined treatment of Fas signaling or autophagy inhibitors in triple negative breast cancer cells

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The anti-tumor efficiency of pterostilbene is promoted with a combined treatment of Fas signaling or autophagy inhibitors in triple negative breast cancer cells

Content Provider	Royal Society of Chemistry (RSC)
Author	Hsu, Kuei-Yang Way, Tzong-Der Kuo, Sheng-Chu Ho, Chi-Tang Chen, Wei-Chih Lin, Ying-Chao Hung, Chao-Ming Yang, Ning-Sun
Copyright Year	2014
Abstract	High expression of vimentin, a canonical mesenchymal marker, is linked with poor prognosis in triple negative breast cancer (TNBC), implying that vimentin may be a potential biomarker in the application of TNBC therapy. Pterostilbene (PTE) has shown anti-invasion activity, and thus, we investigated whether PTE inhibited the epithelial-mesenchymal transition (EMT) in TNBC. Here, we show that PTE decreases the vimentin expression, but that the effect was transient. PTE stimulated Fas signaling, which drives EMT by the ERK1/2 and GSK3β/β-catenin pathways, supporting Fas signaling induction involved in EMT regulation. PTE also triggered autophagy in TNBC. The treatment of TNBC with 3-methyladenine an autophagy inhibitor, not only sustained PTE-inhibited EMT but also significantly promoted anti-proliferation, which indicates that autophagy plays a cyto-protective role and is associated with EMT. Taken together, these data showed that Fas signaling and autophagy accelerated the aggressiveness of TNBC. Inhibition of autophagy or Fas signaling may provide novel targets for TNBC therapy.
Starting Page	1856
Ending Page	1865
Page Count	10
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	5
Issue Number	8
Journal	Food & Function
DOI	10.1039/c4fo00145a
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	PTE Vimentin Triple-negative breast cancer TNBC Biomarker Pterostilbene Epithelial\u2013mesenchymal transition MAPK3 GSK3B Beta-catenin Autophagy Enzyme inhibitor
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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The anti-tumor efficiency of pterostilbene is promoted with a combined treatment of Fas signaling or autophagy inhibitors in triple negative breast cancer cells

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The anti-tumor efficiency of pterostilbene is promoted with a combined treatment of Fas signaling or autophagy inhibitors in triple negative breast cancer cells