NDLI: Physicochemical properties, antioxidant activities and protective effect against acute ethanol-induced hepatic injury in mice of foxtail millet (<i>Setaria italica</i>) bran oil

Content Provider	Royal Society of Chemistry (RSC)
Author	Cao, Xinmin Cao, Lili Jiang, Shaotong Pang, Min Wang, Lu He, Shujian
Copyright Year	2014
Abstract	This study was designed to investigate physicochemical characterization of the oil extracted from foxtail millet bran (FMBO), and the antioxidant and hepatoprotective effects against acute ethanol-induced hepatic injury in mice. GC-MS analysis revealed that unsaturated fatty acids (UFAs) account for 83.76% of the total fatty acids; in particular, the linoleic acid (C18:2) is the predominant polyunsaturated fatty acid (PUFA), and the compounds of squalene and six phytosterols (or phytostanols) were identified in unsaponifiable matter of FMBO. The antioxidant activity examination of FMBO in vitro showed highly ferric-reducing antioxidant power and scavenging effects against DPPH· and HO· radicals. Furthermore, the protective effect of FMBO against acute hepatic injuries induced by ethanol was verified in mice. In this, intragastric administration with different dosages of FMBO in mice ahead of acute ethanol administration could observably antagonize the ethanol-induced increases in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), and the hepatic malondialdehyde (MDA) levels, respectively, along with enhanced hepatic superoxide dismutase (SOD) levels relative to the control. Hepatic histological changes were also observed and confirmed that FMBO is capable of attenuating ethanol-induced hepatic injury.
Starting Page	1763
Ending Page	1770
Page Count	8
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	5
Issue Number	8
Journal	Food & Function
DOI	10.1039/c4fo00106k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	MDA Foxtail millet Antioxidant Hepatoprotection Gas chromatography\u2013mass spectrometry Carboxylic acid Fatty acid Squalene Saponification DPPH Ethanol Alanine transaminase Aspartate transaminase Triglyceride Malondialdehyde Superoxide dismutase
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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