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| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Li, Longnan Le, Guowei Sun, Jin Zheng, Jing Shi, Yonghui Wang, Bin |
| Copyright Year | 2014 |
| Abstract | High-fat diet (HFD)-induced obesity is often associated with immune dysfunction. Resveratrol (trans-3,5,4′-trihydroxystilbene), which has well-founded immunity-related beneficial properties, was used to elucidate the regulatory effect on glucose metabolism and T-lymphocyte subsets in the development of HFD-induced obesity. Resveratrol, being associated with decreases of plasma leptin and plasma lipids and the release of oxidative stress, significantly decreased the body weight and fat masses in HF mice after 26 weeks of feeding. Furthermore, resveratrol decreased the fasting blood glucose and fasting plasma insulin and increased the CD3+CD4+/CD3+CD8+ subsets percentages and the regulatory T cells (Tregs) production after 13 and 26 weeks of feeding. The results indicate that resveratrol, as an effective supplement for HFD, maintained glucose homeostasis by activating the PI3K and SIRT1 signaling pathways. Moreover, resveratrol activated the Nrf2 signaling pathway-mediated antioxidant enzyme expression to alleviate inflammation by protecting against oxidative damage and T-lymphocyte subset-related chronic inflammatory response in the development of HFD-induced obesity. |
| Starting Page | 1452 |
| Ending Page | 1463 |
| Page Count | 12 |
| File Format | HTM / HTML PDF |
| ISSN | 20426496 |
| Volume Number | 5 |
| Issue Number | 7 |
| Journal | Food & Function |
| DOI | 10.1039/c3fo60714c |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | HFD Obesity Resveratrol Blood sugar Metabolism T cell Blood plasma Leptin Oxidative stress Adipocyte Fasting Insulin T helper cell Cytotoxic T cell Homeostasis Phosphoinositide 3-kinase Sirtuin 1 NFE2L2 Antioxidant Enzyme Inflammation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Food Science |
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