NDLI: Virgin olive oil phenolics extract inhibit invasion of HT115 human colon cancer cells <i>in vitro</i> and <i>in vivo</i>

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Food & Function Vol - 5 Issue - 6

Food & Function Vol - 5 Issue - 5

Food & Function Vol - 5 Issue - 4

Food & Function Vol - 5 Issue - 3

Food & Function Vol - 5 Issue - 2

Food & Function Vol -4

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Food & Function Vol -1

Virgin olive oil phenolics extract inhibit invasion of HT115 human colon cancer cells in vitro and in vivo

Content Provider	Royal Society of Chemistry (RSC)
Author	Allsopp, Philip Servili, Maurizio Hashim, Yumi Z. H.-Y. Brown, Emma M. McCann, Mark J. Worthington, Jenny Rowland, Ian R. Gill, Chris I. R. Ternan, Nigel G. Esposto, Sonia
Copyright Year	2014
Abstract	The decreased cancer risk associated with consumption of olive oil may be due to the presence of phenolics which can modulate pathways including apoptosis and invasion that are relevant to carcinogenesis. We have previously shown that a virgin olive oil phenolics extract (OVP) inhibited invasion of HT115 colon cancer cells in vitro. In the current study we assessed the in vitro effects of OVP (25 μg mL−1) on HT115 cell migration, spreading and integrin expression. Furthermore, the anti-metastatic activity of OVP – at a dose equivalent to 25 mg per kg per day for 2, 8 or 10 weeks – was assessed in a Severe Combined ImmunoDeficiency (SCID) Balb-c mouse model. After 24 h OVP did not inhibit cell migration but significantly reduced cell spreading on fibronectin (65% of control; p < 0.05) and expression of a range of α and β integrins was modulated. In vivo, OVP by gavage significantly (p < 0.05) decreased not only tumour volume but also the number of metastases in SCID Balb-c mice. Collectively, the data suggest that – possibly through modulation of integrin expression – OVP decreases invasion in vitro and also inhibits metastasis in vivo.
Starting Page	1513
Ending Page	1519
Page Count	7
File Format	HTM / HTML PDF
ISSN	20426496
Volume Number	5
Issue Number	7
Journal	Food & Function
DOI	10.1039/c4fo00090k
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	OVP Cancer Olive oil Apoptosis Carcinogenesis Colorectal cancer Integrin Severe combined immunodeficiency Mouse Fibronectin Force-feeding Metastasis
Content Type	Text
Resource Type	Article
Subject	Medicine Food Science

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