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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Talker, Stephanie C. Käser, Tobias Reutner, Katharina Sedlak, Corinna Mair, Kerstin H. Koinig, Hanna Graage, Robert Viehmann, Miriam Klingler, Eva Ladinig, Andrea Ritzmann, Mathias Saalmüller, Armin Gerner, Wilhelm |
| Description | Country affiliation: Austria Author Affiliation: Talker SC ( Institute of Immunology, Department of Pathobiology, University of Veterinary Medicine Vienna, Austria.) |
| Abstract | Detailed information concerning the development of the immune system in young pigs is still rudimental. In the present study, we analyzed changes in phenotype and absolute numbers of natural killer cells, γδ T cells, T helper cells, regulatory T cells and cytolytic T cells in the blood of pigs from birth to six months of age. For each lymphocyte subpopulation, a combination of lineage and differentiation markers was investigated by six-color flow cytometry. Major findings were: (i) absolute numbers of γδ T cells strongly increased from birth until 19-25 weeks of age, indicating an important role for these cells during adolescence; (ii) phenotype of T helper cells changed over time from CD8 (-)SLA-DR(-)CD27(+) towards CD8 (+)SLA-DR(+)CD27(-) but CD45RC(-) T helper cells were found immediately after birth, therefore questioning the role of this marker for the identification of T-helper memory cells; (iii) for cytolytic T cells, putative phenotypes for early effector (CD3(+)CD8 ß(+)perforin(+)CD27(dim)) and late effector or memory cells (CD3(+)CD8 ß(+)perforin(+)CD27(-)) could be identified. |
| File Format | HTM / HTML |
| ISSN | 0145305X |
| Issue Number | 1 |
| Volume Number | 40 |
| e-ISSN | 18790089 |
| Journal | Developmental & Comparative Immunology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-05-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Immunology Killer Cells, Natural Immunology Swine T-lymphocyte Subsets T-lymphocytes, Cytotoxic T-lymphocytes, Helper-inducer T-lymphocytes, Regulatory Animals Animals, Newborn Cell Differentiation Immunologic Memory Immunophenotyping Receptors, Antigen, T-cell, Gamma-delta Metabolism Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Developmental Biology Immunology |
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