NDLI: Enhanced Oxidative Stress and Other Potential Biomarkers for Retinopathy in Type 2 Diabetics: Beneficial Effects of the Nutraceutic Supplements

Content Provider	PubMed Central
Author	Roig-revert, María J. Antonio, Lleó-pérez Vicente, Zanón-moreno Bárbara, Vivar-llopis Juan, Marín-montiel Rosa, Dolz-marco Luis, Alonso-muñoz Mara, Albert-fort López-gálvez, María I. David, Galarreta-mira García-esparza, María F. Carmen, Galbis-estrada Marco-ramirez, Carla Shoaie-nia, Kian Sanz-gonzález, Silvia M. Vicente, Vila-bou Elena, Bendala-tufanisco García-medina, José J. Nucci, Carlo Roberto, Gallego-pinazo Arévalo, J. Fernando Pinazo-durán, Maria D. Valencia, Study On Diabetic Retinopathy (vsdr)
Copyright Year	2015
Description	Valencia Study on Diabetic Retinopathy (VSDR)
Abstract	We have studied the global risk of retinopathy in a Mediterranean population of type 2 diabetes mellitus (T2DM) patients, according to clinical, biochemical, and lifestyle biomarkers. The effects of the oral supplementation containing antioxidants/omega 3 fatty acids (A/ω3) were also evaluated. Suitable participants were distributed into two main groups: (1) T2DMG (with retinopathy (+DR) or without retinopathy (−DR)) and (2) controls (CG). Participants were randomly assigned (+A/ω3) or not (−A/ω3) to the oral supplementation with a daily pill of Nutrof Omega (R) for 18 months. Data collected including demographics, anthropometrics, characteristics/lifestyle, ophthalmic examination (best corrected visual acuity, ocular fundus photographs, and retinal thickness as assessed by optical coherence tomography), and blood parameters (glucose, glycosylated hemoglobin, triglycerides, malondialdehyde, and total antioxidant capacity) were registered, integrated, and statistically processed by the SPSS 15.0 program. Finally, 208 participants (130 diabetics (68 +DR/62 −DR) and 78 controls) completed the follow-up. Blood analyses confirmed that the T2DMG+DR patients had significantly higher oxidative stress (p < 0.05), inflammatory (p < 0.05), and vascular (p < 0.001) risk markers than the T2DMG−DR and the CG. Furthermore, the A/ω3 oral supplementation positively changed the baseline parameters, presumptively by inducing metabolic activation and ameliorating the ocular health after 18 months of supplementation.
Related Links	http://dx.doi.org/10.1155/2015/408180
Starting Page	408180
File Format	PDF
ISSN	23146133
e-ISSN	23146141
Journal	BioMed Research International
Volume Number	2015
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2015-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

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