NDLI: Metabolomic Profiling in Perinatal Asphyxia: A Promising New Field

Content Provider	PubMed Central
Author	Denihan, Niamh M. Boylan, Geraldine B. Murray, Deirdre M.
Copyright Year	2015
Abstract	Metabolomics, the latest “omic” technology, is defined as the comprehensive study of all low molecular weight biochemicals, “metabolites” present in an organism. As a systems biology approach, metabolomics has huge potential to progress our understanding of perinatal asphyxia and neonatal hypoxic-ischaemic encephalopathy, by uniquely detecting rapid biochemical pathway alterations in response to the hypoxic environment. The study of metabolomic biomarkers in the immediate neonatal period is not a trivial task and requires a number of specific considerations, unique to this disease and population. Recruiting a clearly defined cohort requires standardised multicentre recruitment with broad inclusion criteria and the participation of a range of multidisciplinary staff. Minimally invasive biospecimen collection is a priority for biomarker discovery. Umbilical cord blood presents an ideal medium as large volumes can be easily extracted and stored and the sample is not confounded by postnatal disease progression. Pristine biobanking and phenotyping are essential to ensure the validity of metabolomic findings. This paper provides an overview of the current state of the art in the field of metabolomics in perinatal asphyxia and neonatal hypoxic-ischaemic encephalopathy. We detail the considerations required to ensure high quality sampling and analysis, to support scientific progression in this important field.
Related Links	http://dx.doi.org/10.1155/2015/254076
Starting Page	254076
File Format	PDF
ISSN	23146141
e-ISSN	23146141
Journal	BioMed Research International
Volume Number	2015
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2015-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Metabolomic profiling in perinatal asphyxia: a promising new field.

Perinatal Pharmacology

MicroRNAs: Promising New Antiangiogenic Targets in Cancer

Helical Tomotherapy for Inoperable Breast Cancer: A New Promising Tool

A Swine Model of Neonatal Asphyxia

3,3′-Diindolylmethane: A Promising Sensitizer of γ-Irradiation

Perinatal Health Statistics as the Basis for Perinatal Quality Assessment in Croatia

Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach.

Metabolomic profiling in blood from umbilical cords of low birth weight newborns

Metabolomic Profiling in Perinatal Asphyxia: A Promising New Field

Similar Documents

Metabolomic profiling in perinatal asphyxia: a promising new field.

Perinatal Pharmacology

MicroRNAs: Promising New Antiangiogenic Targets in Cancer

Helical Tomotherapy for Inoperable Breast Cancer: A New Promising Tool

A Swine Model of Neonatal Asphyxia

3,3′-Diindolylmethane: A Promising Sensitizer of γ-Irradiation

Perinatal Health Statistics as the Basis for Perinatal Quality Assessment in Croatia

Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach.

Metabolomic profiling in blood from umbilical cords of low birth weight newborns

Metabolomic Profiling in Perinatal Asphyxia: A Promising New Field