NDLI: Prognostic Value of 99mTc-Pertechnetate Thyroid Scintigraphy in Radioiodine Therapy in a Cohort of Chinese Graves' Disease Patients: A Pilot Clinical Study

Content Provider	PubMed Central
Author	Hou, Haifeng Shu, Hu Fan, Rong Sun, Wen Zhang, Xiaofei Tian, Mei
Copyright Year	2015
Abstract	Objectives. This study is to assess the prognostic value of 99mTc-pertechnetate thyroid scintigraphy for predicting the outcomes of fixed low dose of radioiodine therapy (RIT) in a cohort of Chinese Graves' disease (GD) patients. Materials and Methods. This is a retrospective study of GD patients who received RIT with a single dose of radioiodine (5 mCi). All the patients received 99mTc-pertechnetate thyroid scintigraphy prior to RIT. Thyroid mass, 99mTc-pertechnetate uptake, gender, age at diagnosis, duration of the disease, ophthalmopathy, and serum levels of FT4, FT3, TT4, and TT3 prior to RIT were analyzed as potential interference factors for outcomes of RIT. Results. One hundred and eighteen GD patients who completed RIT were followed up for 12 months. The outcomes (euthyroidism, hypothyroidism, and hyperthyroidism) were found to be significantly associated with thyroid mass and 99mTc-pertechnetate uptake. Patients with thyroid mass ≤ 40.1 g or 99mTc-pertechnetate uptake ≤ 15.2% had higher treatment success. Conclusions. A fixed low dose of 5 mCi radioiodine seems to be practical and effective for the treatment of Chinese GD patients with thyroid mass ≤ 40.1 g and 99mTc-pertechnetate uptake ≤ 15.2%. This study demonstrates 99mTc-pertechnetate thyroid scintigraphy is an important prognostic factor for predicting the outcomes of RIT.
Related Links	http://dx.doi.org/10.1155/2015/974689
Starting Page	974689
File Format	PDF
ISSN	23146141
e-ISSN	23146141
Journal	BioMed Research International
Volume Number	2015
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2015-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

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