NDLI: Patient-Specific Simulation of Coronary Artery Pressure Measurements: An In Vivo Three-Dimensional Validation Study in Humans

Content Provider	PubMed Central
Author	Siogkas, Panagiotis K. Papafaklis, Michail I. Sakellarios, Antonis I. Stefanou, Kostas A. Bourantas, Christos V. Athanasiou, Lambros S. Exarchos, Themis P. Naka, Katerina K. Michalis, Lampros K. Parodi, Oberdan Fotiadis, Dimitrios I.
Copyright Year	2015
Abstract	Pressure measurements using finite element computations without the need of a wire could be valuable in clinical practice. Our aim was to compare the computed distal coronary pressure values with the measured values using a pressure wire, while testing the effect of different boundary conditions for the simulation. Eight coronary arteries (lumen and outer vessel wall) from six patients were reconstructed in three-dimensional (3D) space using intravascular ultrasound and biplane angiographic images. Pressure values at the distal and proximal end of the vessel and flow velocity values at the distal end were acquired with the use of a combo pressure-flow wire. The 3D lumen and wall models were discretized into finite elements; fluid structure interaction (FSI) and rigid wall simulations were performed for one cardiac cycle both with pulsatile and steady flow in separate simulations. The results showed a high correlation between the measured and the computed coronary pressure values (coefficient of determination [r 2] ranging between 0.8902 and 0.9961), while the less demanding simulations using steady flow and rigid walls resulted in very small relative error. Our study demonstrates that computational assessment of coronary pressure is feasible and seems to be accurate compared to the wire-based measurements.
Related Links	http://dx.doi.org/10.1155/2015/628416
Starting Page	628416
File Format	PDF
ISSN	23146133
e-ISSN	23146141
Journal	BioMed Research International
Volume Number	2015
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2015-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology

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