NDLI: Fabrication of a novel Multi-Electrode Array (MEA) biochip using polyester insulated electrodes with microwell features for cardiomyocyte analysis

Content Provider	IEEE Xplore Digital Library
Author	Flaherty, O.M. Xiaoyun Cui Rajamohan, D. Anderson, D. Hutt, D. Denning, C. Conway, P.P. West, A.A.
Copyright Year	2011
Description	Author affiliation: The Wolfson School of Mechanical and Manufacturing Engineering, Loughborough University, Leicestershire. LE11 3TU. UK (Flaherty, O.M.; Xiaoyun Cui; Hutt, D.; Conway, P.P.; West, A.A.) \|\| The Wolfson Centre for Stem Cells, Tissue Engineering & Modelling (STEM), Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottinghamshire. NG7 2RD. UK (Rajamohan, D.; Anderson, D.; Denning, C.)
Abstract	There is an increasing interest in Multi-Electrode Array (MEA) technology arising from a diversity of bio-scientific areas, which is especially strong in stem cell, drug discovery or safety pharmacology applications. There are limitations in the quantity of useful data captured during an MEA-based trial that can be attributed to reasons such as the time intensive nature of MEA application, the subsequent time-consuming and often complex data analysis, and the lack of standardisation between applications. MEAs that are more widely applicable to the diverse and demanding requirements of applications in research and industry are necessary to improve efficiencies and reduce costs. Existing electronics manufacturing approaches have been brought together here to realise a novel MEA biochip. Fabrication of this MEA biochip design that is suited to higher throughput screening of cardiomyocyte-based drug trials has been pursued. The MEA biochip has been successfully manufactured using approaches that are novel in this application domain. Results achieved have provided a device that has supported cell survival and attachment. Assessment of practical bioscientific protocols using this device compared to a standard model indicates that the design changes implemented in this setting could save users up to approximately £115 per experiment, in terms of labour cost savings alone.
Starting Page	1
Ending Page	6
File Size	750892
Page Count	6
File Format	PDF
ISBN	9781467306942
e-ISBN	9780956808608
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-09-12
Publisher Place	United Kingdom
Access Restriction	Subscribed
Rights Holder	IMAPS
Subject Keyword	Melinex® Film Excimer Laser Biological system modeling Computational modeling Films Cardiomyocyte Media Substrates Biomedical imaging Micro-electrode array
Content Type	Text
Resource Type	Article

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