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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Muneeb Zia Chaoqi Zhang Thadesar, P. Hookway, T. Taiyun Chi Gonzalez, J. McDevitt, T. Hua Wang Bakir, M.S. |
| Copyright Year | 2015 |
| Description | Author affiliation: Gladstone Inst. of Cardiovascular Disease, San Francisco, CA, USA (Hookway, T.; McDevitt, T.) || Dept. of Electr. & Comput. Eng., Georgia Inst. of Technol., Atlanta, GA, USA (Muneeb Zia; Chaoqi Zhang; Thadesar, P.; Taiyun Chi; Gonzalez, J.; Hua Wang; Bakir, M.S.) |
| Abstract | A silicon membrane acting as an interface layer between live cells and the sensing electronics enabling low-cost, high-throughput bio-sensing is proposed; the interface is capable of supporting high pixel density allowing accurate image mapping. Cell attachment and growth was carried out on five different silicon based surfaces and compared to the standard Tissue Culture Polystyrene (TCPS) surface in order to optimize the selection process of the interface material; cell imaging is performed after 48 hours to study the effect of different surface variations (different materials on silicon, presence of metal, increased surface roughness due to CMP, etc.) on cell adhesion and growth. The results show that cells successfully adhere and grow onto the sensing electrodes for all the surfaces under test after the first 48 hours. Key enabling technologies for high pixel density membranes are also presented. |
| Starting Page | 1 |
| Ending Page | 4 |
| File Size | 1191395 |
| Page Count | 4 |
| File Format | |
| e-ISBN | 9781479972340 |
| DOI | 10.1109/BioCAS.2015.7348428 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2015-10-22 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Electrodes bio-sensing platform Cell growth system integration Silicon Biomembranes Sensors CMOS integrated circuits Rough surfaces TSVs Through-silicon vias silicon membranes |
| Content Type | Text |
| Resource Type | Article |
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