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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Nag, S. Lee, P. Herikstad, R. Sng, J. Shih Cheng Yen Thakor, N.V. |
| Copyright Year | 2015 |
| Description | Author affiliation: Dept. of Pharmacology, Nat. Univ. of Singapore, Singapore, Singapore (Sng, J.) || Singapore Inst. for Neurotechnology, Nat. Univ. of Singapore, Singapore, Singapore (Nag, S.; Herikstad, R.; Shih Cheng Yen; Thakor, N.V.) || Singapore Inst. for Clinical Sci., A*star, Singapore, Singapore (Lee, P.) |
| Abstract | The techniques of optogenetic stimulation and neural signal recording can be coupled together in order to realize a closed loop neural interface. An improved multifunction system has been presented that is able to generate single or multi-wavelength optical pulses as well as measure evoked neural potentials. The optical stimulator is based on blue (470 nm) and yellow (592 nm) LEDs. The neural recording amplifier consists of a low noise chip with an analog-to-digital converter (ADC), an impedance measurement hardware and a digital communication logic. In addition, wireless power and data transfer capabilities makes the system useful for a range of in-vivo studies. A safety feature against high temperature induced neural damage has also been incorporated. The entire system weighs approximately 4 gms and is packaged using an FDA-compliant biocompatible polymer for reliable and waterproof operation. In-vivo stimulation and recording experiments have been performed in the visual and motor cortices of transgenic CHR2 mice under anesthetized and partially awake conditions. |
| Starting Page | 1 |
| Ending Page | 4 |
| File Size | 1839705 |
| Page Count | 4 |
| File Format | |
| e-ISBN | 9781479972340 |
| DOI | 10.1109/BioCAS.2015.7348341 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2015-10-22 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Biomedical optical imaging Stimulated emission Optical recording Light emitting diodes Mice Optical sensors Optical pulses |
| Content Type | Text |
| Resource Type | Article |
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