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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Yan-juan Zhu Hai-bo Zhang Li-rong Liu Bin Yuan Fu-li Zhang Jian-ping Bai Yong Li Yi-hong Liu Yan-chun Qu Xin Qu |
| Copyright Year | 2014 |
| Description | Author affiliation: Dept. of Oncology, Guangdong Provincial Hosp. of Chinese Med., Guangzhou, China (Yan-juan Zhu; Hai-bo Zhang; Li-rong Liu; Bin Yuan; Fu-li Zhang; Jian-ping Bai; Yong Li; Yi-hong Liu; Yan-chun Qu; Xin Qu) |
| Abstract | Purpose The Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR-TKIs) have been used as first line treatment in advanced Non-Small Cell Lung Cancer (NSCLC) with sensitive EGFR gene mutations. In clinical practice, we found that the rate of EGFR gene mutation in patients with Yin-cold syndrome type in traditional Chinese medicine (TCM) theory was higher than those with Yang-heat type syndrome. The purpose of this study was to identify the relationship between the TCM syndrome type and the EGFR gene status as well as efficacy of EGFR-TKIs in NSCLC patients. Methods From March 2013 to January 2014, we prospectively studied all the patients who are newly diagnosed with NSCLC without prior anticancer therapy, or those with recurrence with an interval of more than 6 moths from last anticancer therapy to the recurrence. The symptoms and signs which can help for the TCM syndrome type diagnosis were recorded. The EGFR gene statuses were also tested. The Yang-heat or Yin-cold syndrome types of TCM were diagnosed respectively by 3 TCM experts of our hospital to decide the TCM syndrome type. The relationship between the EGFR gene status and the TCM syndrome type were analyzed. The patients were followed up until August 2014. Results A total of 73 consecutive patients were enrolled in our study. 32 patients (43.84%) were with the Yin-cold syndrome type according to the TCM theory, while the other 41 patients (56.16%) were with the Yang-heat type. 17 patients (53.13%) in the Yin-cold group, while only 10 patients (24.39%) in the Yang-heat group, were with sensitive EGFR gene mutation (p=0.0120). 1 in the Yin-cold group and 1 in the Yang-heat group were with T790M at the exon 20 of EGFR gene. The EGFR genes were wild type in the other 44 patients. No significant difference was seen in PFS or OS between the TCM syndrome groups for those 22 patients who took EGFR-TKIs. Conclusion Patients with Yin-cold TCM syndrome type have more chance with sensitive EGFR gene mutation. However, no relationship was seen between the efficacy of EGFR-TKIs and TCM syndrome type. |
| Starting Page | 33 |
| Ending Page | 35 |
| File Size | 232005 |
| Page Count | 3 |
| File Format | |
| ISBN | 9781479956692 |
| DOI | 10.1109/BIBM.2014.6999399 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2014-11-02 |
| Publisher Place | UK |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Patents Yin-cold TCM syndrome type Hospitals Yang-heat TCM syndrome type None small cell lung cancer Lungs Medical diagnostic imaging Epidermal growth factor receptor Cancer |
| Content Type | Text |
| Resource Type | Article |
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