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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Ivanov, M. Ingelman-Sundberg, M. Kals, M. Milani, L. |
| Copyright Year | 2014 |
| Description | Author affiliation: Estonian Genome Center, Univ. of Tartu, Tartu, Estonia (Kals, M.; Milani, L.) || Dept. of Physiol. & Pharmacology, Karolinska Institutet, Stockholm, Sweden (Ivanov, M.; Ingelman-Sundberg, M.) |
| Abstract | So far, bisulfite sequencing has been considered as the “gold standard” method for the detection of DNA methylation. The results of whole-genome bisulfite next-generation sequencing (WG-BS-Seq) allowed scientists to conclude that the vast majority of CpG sites in genomic DNA from human and animal tissues are invariably hypermethylated. Only a small proportion (≤ 10-15%) of CpG sites was found to manifest variable degree of methylation between different tissues or among individuals. Moreover, such variably methylated CpG sites were believed to occur almost exclusively within extended clusters (differentially methylated regions, or DMRs). |
| Starting Page | 6 |
| Ending Page | 6 |
| File Size | 134988 |
| Page Count | 1 |
| File Format | |
| ISBN | 9781479956692 |
| DOI | 10.1109/BIBM.2014.6999389 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2014-11-02 |
| Publisher Place | UK |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Sequential analysis Protocols Genomics DNA Liver Bioinformatics Next generation networking |
| Content Type | Text |
| Resource Type | Article |
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