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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | SeungHeui Ryu NaHyun Kwak DoHoon Lee |
| Copyright Year | 2014 |
| Description | Author affiliation: Dept. of Inf. Technol., SillaJen Inc., Pusan, South Korea (NaHyun Kwak) || Dept. of Comput. Sci. & Eng., Pusan Nat. Univ., Pusan, South Korea (SeungHeui Ryu; DoHoon Lee) |
| Abstract | The use of vaccinia virus, an oncolytic virus, in cancer immune therapy enhances the overall immune response. The mechanism of immune response against cancer and virus infection is similar. We found sequence relationships between vaccinia virus proteins and human proteins that are often regarded as hallmarks of cancer. From comparing human and vaccinia virus protein sequences, genetically engineered viruses associated with immune response have been used for cancer immune therapy in many clinical trials. Using published papers about cancer immunology, we classified proteins as either positively or negatively associated with cancer immune therapy. We searched for sequence relationships between human proteins and vaccinia virus proteins that are related to the classified proteins. |
| Starting Page | 285 |
| Ending Page | 288 |
| File Size | 277702 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781479956692 |
| DOI | 10.1109/BIBM.2014.6999169 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2014-11-02 |
| Publisher Place | UK |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Proteins Visualization cancer therapy immune response Medical treatment sequence analyse oncolytic virus protein Viruses (medical) Cancer Immune system Tumors |
| Content Type | Text |
| Resource Type | Article |
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