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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Guang Zheng Rong Li Huanhuan Shi Qi Xiao Wenpeng Xu Ying Wang Cheng Lu Aiping Lu |
| Copyright Year | 2014 |
| Description | Author affiliation: IBRCM, China Acad. of Traditional Chinese Medicines, Beijing, China (Cheng Lu; Aiping Lu) || Sch. of Inf. Sci.-Eng., Lanzhou Univ., Lanzhou, China (Guang Zheng; Rong Li; Huanhuan Shi; Qi Xiao; Wenpeng Xu; Ying Wang) |
| Abstract | Major depression (MD) is a major public health problem which has a substantial impact on individuals and society. Although it is usually treated with antidepressant in primary care, these therapies accompanied with serious side effects. In the clinic of Chinese medicine, Xiao-Yao-San is the first option for MD with little side effects. Although with clear therapeutic effects, its therapeutic mechanism is obscure. In this study, by integrating leading biomedical knowledge databases, though bioinformatics analysis, we explored the potential therapeutic mechanism of Xiao-Yao-San for MD. The therapeutic mechanism analysis covers aspects of Chinese herbal medicine, chemical compound, target protein, OMIM genes, and pathways enriched. As a result, Xiao-Yao-San's 4 target proteins e.g., ADRB2R, B2AR, ADRB2, and MC4R can be matched in MD's OMIM genes which are mainly enriched in pathways of signal transduction. This research demonstrates that Xiao-Yao-San's target proteins may regulate a wide range of different pathways associated with MD. |
| Starting Page | 229 |
| Ending Page | 234 |
| File Size | 2042208 |
| Page Count | 6 |
| File Format | |
| ISBN | 9781479956692 |
| DOI | 10.1109/BIBM.2014.6999365 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2014-11-02 |
| Publisher Place | UK |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Proteins Protein engineering molecular mechanism Databases Xiao-Yao-San traditional Chinese medicine Compounds Chemical compounds major depression Diseases |
| Content Type | Text |
| Resource Type | Article |
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