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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Kimin Oh Taeho Hwang Kihoon Cha Gwan-Su Yi |
| Copyright Year | 2014 |
| Description | Author affiliation: Dept. of Bio & Brain Eng., KAIST, Daejeon, South Korea (Kimin Oh; Kihoon Cha; Gwan-Su Yi) || Dept. of Inf. & Commun. Eng., KAIST, Daejeon, South Korea (Taeho Hwang) |
| Abstract | Characterizing the transcriptomic change between human and chimpanzee brains can provide clues for identifying the cellular functions underlying human's enhanced cognition and the increased vulnerability to the neurodegenerative and psychiatric disorders. Despite some successes, previous studies might have limited sensitivity to detect specific cellular functions since the focus has been only on the strong signals appeared by individual genes or pairs. To overcome these limitations, we carried out two functional module-centric transcriptome analyses. We evaluated the coordinated differential expression and the altered coexpression within the various types of functional modules. In our comparative assessment, the functional module-centric coexpression analysis identified the most extensive functional implications, in comparison to the conventional gene-centric and functional module-centric differential expression analyses. Through the functional module-centric coexpression analysis, we detected several human-specific modules associated with human-specific phenotypes related on neurobiological processes. In summary, our results suggest the rearrangement of transcriptional regulation over individual and multiple functional modules as a plausible basis of human brain specializations. |
| Starting Page | 162 |
| Ending Page | 167 |
| File Size | 450473 |
| Page Count | 6 |
| File Format | |
| ISBN | 9781479956692 |
| DOI | 10.1109/BIBM.2014.6999146 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2014-11-02 |
| Publisher Place | UK |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Proteins functional module Sensitivity human brain Neurons Biological processes differential expression Cognition Gene expression coexpression Diseases transcriptome analyses |
| Content Type | Text |
| Resource Type | Article |
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