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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Guang Zheng Ting Hao Rong Li Lingru Wang Kai Cui Cheng Lu Aiping Lu |
| Copyright Year | 2014 |
| Description | Author affiliation: IBRCM, China Acad. of traditional Chinese Medicines, Beijing, China (Cheng Lu; Aiping Lu) || Sch. of Inf. Sci.-Eng., Lanzhou Univ., Lanzhou, China (Guang Zheng; Ting Hao; Rong Li; Lingru Wang; Kai Cui) |
| Abstract | Fang-Feng-Tang is a Chinese herbal formula which is designed to treat syndrome Feng-Han-Shi-Bi for rheumatoid arthritis (RA). Although its therapeutic effects are widely accepted, its mechanism is still obscure. In this study, by integrating leading knowledge databases of associated different domains, we explored Fang-Feng-Tang's potential therapeutic agents for RA through targeted pathway hierarchies. The molecule mechanism analysis includes compositional herbal medicine, chemical compound, target protein, and pathways enriched. Target proteins are restricted with RA OMIM genes and FDA approved RA drug targets for partial validation. As a result, 8 target proteins were matched and they are UGT1A9, GNT1, UGT1, JAK3, CCR2/5, and CMKBR2/5. What's more, they are mainly involved in pathways of signal transduction, metabolism, immune system, and disease. This research demonstrates that Feng-Feng-Tang's target proteins may regulate a wide range of different systems. This might indicate that Chinese herbal formula's therapeutic effects can be demonstrated through system-level regulation rather than targeting disease specified genes or proteins. |
| Starting Page | 235 |
| Ending Page | 238 |
| File Size | 1987913 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781479956692 |
| DOI | 10.1109/BIBM.2014.6999366 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2014-11-02 |
| Publisher Place | UK |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Proteins Protein engineering molecular mechanism Databases traditional Chinese medicine Fang-Feng-Tang Arthritis Chemical compounds rheumatoid arthritis Chemicals Diseases |
| Content Type | Text |
| Resource Type | Article |
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