Please wait, while we are loading the content...
| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Jiangwen Sun Jinbo Bi Kranzler, H.R. |
| Copyright Year | 2014 |
| Description | Author affiliation: Dept. of Comput. Sci. & Eng., Univ. of Connecticut, Storrs, CT, USA (Jiangwen Sun; Jinbo Bi) || Treatment Res. Center, Univ. of Pennsylvania, Philadelphia, PA, USA (Kranzler, H.R.) |
| Abstract | An important approach to reducing missing heritability and enhancing success of genome-wide association studies (GWAS) for complex diseases is the identification of traits that are highly heritable and homogeneous in their etiology. Many approaches have been proposed to define such traits based on either cluster analysis or pedigree-based heritable component analysis. None of the existing methods, however, exploit the dense genome-wide genotypic data that are now readily available from GWAS, and with exome and whole genome sequencing more data will be available in the future. Moreover, because a phenotype can vary with respect to a covariate, such as age or race. The fixed effect due to the covariates may lead to a spuriously elevated estimate of heritability. Existing heritable component analysis methods have not considered covariate effects. We propose an optimization approach to identify composite traits with high heritability as a function of multiple phenotypic variables where heritability is estimated from genome-wide single neucleotide polymorphisms (SNPs). Our approach can model the covariate effects within heritability analysis. The proposed optimization problem can be efficiently solved by a sequential quadratic programming algorithm. A case study demonstrates the effectiveness of the proposed approach for finding composite traits with high SNP-based heritability. |
| Starting Page | 340 |
| Ending Page | 343 |
| File Size | 277698 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781479956692 |
| DOI | 10.1109/BIBM.2014.6999181 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2014-11-02 |
| Publisher Place | UK |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | phenotype-genotype analysis Genomics Educational institutions quadratic optimization Bioinformatics Sun Optimization chip heritability Diseases |
| Content Type | Text |
| Resource Type | Article |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|