NDLI: Flexible micro sensor for intravascular vulnerable plaque diagnostic with electrical impedance spectroscopy

Content Provider	IEEE Xplore Digital Library
Author	Xiaoxiao Zhang Lei Xu Juhyun Lee Rongsong Li Yang Liu Shapero, A. Tzung Hsiai Yu-Chong Tai
Copyright Year	2015
Description	Author affiliation: Caltech Micromachining Lab., California Inst. of Technol., Pasadena, CA, USA (Xiaoxiao Zhang; Lei Xu; Yang Liu; Shapero, A.; Yu-Chong Tai) \|\| Dept. of Med., Univ. of California Los Angeles, Los Angeles, CA, USA (Juhyun Lee; Rongsong Li; Tzung Hsiai)
Abstract	Studies have shown emerging evidence that rupture of coronary plaque containing a lipid-rich core with subsequent thrombus formation is the most frequent mechanism by which atherosclerosis leads to the acute ischaemic syndromes of unstable angina, acute myocardial infarction, and often times, sudden cardiac death. However, since the lumen is not significantly blocked in these cases, such “vulnerable” plaques show noncritical stenosis in X-ray angiography and Intravascular Ultrasound (IVUS), tools currently available to diagnose coronary artery disease. The ability to distinguish such rupture-prone vulnerable plaques remains largely lacking. Therefore it is of great clinical interest to find improved diagnostic techniques to identify and localize such rupture-prone plaques. On the other hand, lipid has significantly lower electrical impedance than the rest of the vessel components in certain frequency bands [1]. We show in this paper that electrical impedance spectroscopy (EIS) technique can be useful to effectively distinguish plaques with such lipid cores. We include in this paper the design rationale of a four electrode EIS sensor and the measurement results between 1 Hz to 300 KHz of ex-vivo mouse aortas with plaque lesions. The impedance modulus over 200 Hz-100 KHz show consistent elevated values 2-5 times higher than their proximity control sites in all three individual mice. The promising ex-vivo EIS results show promising potential for a reliable unstable plaque diagnostic tool for in-vivo catheter integrated intravascular micro EIS sensors.
Sponsorship	IEEE Nanotechnol. Council
Starting Page	243
Ending Page	247
File Size	592326
Page Count	5
File Format	PDF
ISBN	9781467366953
DOI	10.1109/NEMS.2015.7147419
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-04-07
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Impedance Electrodes Sensitivity Lesions Voltage measurement Mice Mathematical model
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in