NDLI: Fabrication of biodegradable polymer microneedle array via CO laser ablation

Content Provider	IEEE Xplore Digital Library
Author	Kun-Tse Tu Chen-Kuei Chung
Copyright Year	2015
Description	Author affiliation: Dept. of Mech. Eng., Nat. Cheng Kung Univ., Tainan, Taiwan (Kun-Tse Tu; Chen-Kuei Chung)
Abstract	Fabrication of biodegradable polylacticcoglycolic acid (PLGA) microneedle array through $CO_{2}$ laser processing have been studied and analyzed. The high-aspect-ratio microneedle mold can be obtained using the rapid and low-cost laser processing compared to conventional photolithography and dry etching processes. The laser processing on PDMS results in the problems of scorches and re-solidification. Here, we use the direct-write laser processing microneedle mold structure on PMMA and then perform two-casting PDMS process to form female microneedle mold. Then pour PLGA into PDMS female mold pre-treated by $O_{2}$ plasma and drying in vacuum chamber. Finally, the complete PLGA microneedle array is released from the PDMS mold which is reusable. The polymer microneedle depth can be from hundreds of micrometers to millimeter that is related to the PMMA structure profile and determined by $CO_{2}$ laser power and scanning speed. The modified integration of laser processing and molding process is maskless, simple, and low-cost for rapid prototyping.
Sponsorship	IEEE Nanotechnol. Council
Starting Page	494
Ending Page	497
File Size	373991
Page Count	4
File Format	PDF
ISBN	9781467366953
DOI	10.1109/NEMS.2015.7147476
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-04-07
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Arrays Laser ablation Power lasers Fabrication Polymers Laser beams PLGA CO2 laser microneedle array
Content Type	Text
Resource Type	Article

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