NDLI: Electromagnetically powered electrolytic pump and thermo-responsive valve for drug delivery

Content Provider	IEEE Xplore Digital Library
Author	Ying Yi Zaher, A. Yassine, O. Buttner, U. Kosel, J. Foulds, I.G.
Copyright Year	2015
Description	Author affiliation: Sch. of Eng., Univ. of British Columbia (UBC), Kelowna, BC, Canada (Zaher, A.) \|\| Electr. Eng. Dept., King Abdullah Univ. of Sci. & Technol. (KAUST), Thuwal, Saudi Arabia (Ying Yi; Yassine, O.; Buttner, U.; Kosel, J.; Foulds, I.G.)
Abstract	A novel drug delivery device is presented, implementing an electrolytic pump and a thermo-responsive valve. The device is remotely operated by an AC electromagnetic field (40.5~58.5 mT, 450 kHz) that provides the power for the pump and the valve. It is suitable for long-term therapy applications, which use a solid drug in reservoir (SDR) approach and avoids unwanted drug diffusion. When the electromagnetic field is on, the electrolytic pump drives the drug towards the valve. The valve is made of a magnetic composite consisting of a smart hydrogel: Poly (N-Isopropylacrylamide) (PNIPAm) and iron powder. The heat generated in the iron powder via magnetic losses causes the PNIPAm to shrink, allowing the drug to flow past it. When the electromagnetic field is off, the PNIPAm swells, sealing the outlet. In the meantime, the bubbles generated by electrolysis recombine into water, causing a pressure reduction in the pumping chamber. This draws fresh fluid from outside the pump into the drug reservoir before the valve is fully sealed. The recombination can be accelerated by a platinum (Pt) coated catalytic reformer, allowing more fluid to flow back to the drug reservoir and dissolve the drug. By repeatedly turning on and off the magnetic field, the drug solution can be delivered cyclically.
Sponsorship	IEEE Nanotechnol. Council
Starting Page	5
Ending Page	8
File Size	521341
Page Count	4
File Format	PDF
ISBN	9781467366953
DOI	10.1109/NEMS.2015.7147344
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-04-07
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Valves Drugs Drug delivery Electromagnetic fields Reservoirs Magnetic liquids Pumps drug delivery PNIPAm valve SDR
Content Type	Text
Resource Type	Article

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