NDLI: In vivo anticoagulation of titanium oxide film coated coronary artery stent prepared by plasma immersion ion implantation and deposition

Content Provider	IEEE Xplore Digital Library
Author	Huang, N. Leng, Y.X. Yang, P. Chen, J.Y. Sun, H. Wang, J. Wan, G.J. Zhao, A.S. Chu, P.K.
Copyright Year	2004
Description	Author affiliation: Key Lab. of Surface Modification of Artificial Organs, Southwest Jiaotong Univ., Chengdu, China (Huang, N.; Leng, Y.X.; Yang, P.; Chen, J.Y.; Sun, H.; Wang, J.; Wan, G.J.; Zhao, A.S.; Chu, P.K.)
Abstract	Summary form only given. Application of coronary stent has successful saved thousands of patients' lives. However insufficient biocompatibility for the stent material such as stainless steel and TiNi alloy has caused the complications such as thrombogenicity and re-stenosis. Surface coating have been suggested to decrease the thrombogenicity of metallic coronary stent. Our previous studies of Ti-O thin films synthesized using plasma immersion ion implantation and deposition (PIIID) have shown that Ti-O films possess superior blood compatibility to the conventional clinically-applied cardiovascular biomaterials. In the work described here we focused our attention on the in vivo anticoagulation behavior of Ti-O thin film coated coronary stent. Coronary stent made from stainless steel were coated by Ti-O thin film and then were implanted into rabbits ventral aoeta for different periods from 4 weeks to 20 weeks under conditions of no anticoagulant. The results of the implantations showed no thrombus formation on the surfaces of the Ti-O thin film coated stents, although serious coagulation had occurred on the surfaces of unmodified stent.
Sponsorship	Plasma Sci. and Applications Committee of the IEEE Nuclear and Plasma Sci. Soc
File Size	80140
File Format	PDF
ISBN	0780383346
ISSN	07309244
DOI	10.1109/PLASMA.2004.1340084
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-07-01
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	In vivo Titanium Arteries Plasma immersion ion implantation Transistors Steel Biological materials Building materials Iron alloys Coatings
Content Type	Text
Resource Type	Article
Subject	Atomic and Molecular Physics, and Optics Condensed Matter Physics Electrical and Electronic Engineering

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