NDLI: Derivation of the input function from dynamic PET images with the HRRT

Content Provider	IEEE Xplore Digital Library
Author	Baudrexel, S. Graf, R. Knoess, C. Vollmar, S. Wienhard, K.
Copyright Year	2004
Description	Author affiliation: Center for Radiol., Frankfurt, Germany (Baudrexel, S.)
Abstract	The High Resolution Research Tomograph (HRRT) with its improved spatial resolution (<2.5 mm), extended axial FOV (25 cm) and high sensitivity offers the possibility to obtain an image derived input function for quantitative PET studies. From the carotid artery in the region of the neck and the petrous bone, the time course of the blood activity can be derived with sufficient counting statistics in human studies. However an online motion correction system is a must. With medium sized animals like cats, the FOV of the HRRT covers both, the brain and the heart, which allows to determine the input function from the blood pool in the heart In cat studies with /sup 15/O-tracers the time course of the tracer activity in arterial blood has been measured with an arteriovenous shunt connected to a blood sampling system. The direct comparison to the input function derived from the blood pool in the left heart chamber in kinetic PET images reconstructed with OSEM3D in short time frames demonstrates the high accuracy and precision of the image derived input function.
Starting Page	3890
Ending Page	3892
File Size	916373
Page Count	3
File Format	PDF
ISBN	0780387007
ISSN	10823654
e-ISBN	0780387015
DOI	10.1109/NSSMIC.2004.1466728
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-10-16
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Positron emission tomography Blood Heart Spatial resolution Image resolution Carotid arteries Neck Bones Statistics Humans
Content Type	Text
Resource Type	Article

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