NDLI: Development of a high resolution SPECT system dedicated to small animal imaging

Content Provider	IEEE Xplore Digital Library
Author	Brasse, D. Piqueras, I. Guyonnet, J.-L.
Copyright Year	2004
Description	Author affiliation: Institut de Recherches Subatomiques, Strasbourg, France (Brasse, D.; Piqueras, I.; Guyonnet, J.-L.)
Abstract	The interest of small animal imaging has been primarily due to the recent advances in genetics with the need to perform longitudinal studies on mice or rat. Recent work has shown that single photon emission computed tomography (SPECT) imaging of small animals can provide high spatial resolution with a high sensitivity where the addition of an X-ray CT system provides the lack of anatomical structures. In our group, we are developing a multi modality system combining X-ray, SPECT and PET imaging system. In this paper, we discuss the development of the SPECT component The key features of the system are i) four individual cameras arranged around the animal, ii) one pinhole aperture and 5 detector modules per camera, iii) a 28 mm focal length, and iii) pixellated scintillator arrays of 2.3/spl times/2.3/spl times/28 mm/sup 3/ VAP:Ce pixels coupled to 8/spl times/8 multi anode PMT. With the pinhole configuration, the axial field of view strongly depends on the axial size of the PMT which is 18.4 mm. In order to increase this field of view, an hybrid collimator made of parallel strip of tungsten is designed. This collimator leads to parallel collimation in the axial direction and pinhole collimation in the transverse direction. The intrinsic resolution of the system is measured to be 1.5 mm in both directions leading to a 1 mm spatial resolution in the center of the field of view using a 0.5 mm diameter pinhole aperture. The predicted absolute detection efficiency of the system is 34.9 cps/MBq and 12.9 cps/MBq for the pinhole and the hybrid collimation. As a conclusion, we propose a modular SPECT system with high spatial resolution combined with high sensitivity.
Starting Page	3868
Ending Page	3871
File Size	1109480
Page Count	4
File Format	PDF
ISBN	0780387007
ISSN	10823654
e-ISBN	0780387015
DOI	10.1109/NSSMIC.2004.1466723
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-10-16
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Image resolution Animals High-resolution imaging Collimators Spatial resolution Optical imaging X-ray imaging Cameras Apertures Genetics
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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