NDLI: A general-spectral method for improved quantitative SPECT imaging of indium-111

Content Provider	IEEE Xplore Digital Library
Author	Moore, S.C. Park, M.-A. El Fakhri, G. Gerbaudo, V.H. Zimmerman, R.E.
Copyright Year	2004
Description	Author affiliation: Dept. of Radiol., Harvard Med. Sch., Boston, MA, USA (Moore, S.C.; Park, M.-A.; El Fakhri, G.; Gerbaudo, V.H.; Zimmerman, R.E.)
Abstract	Improved Indium-111 SPECT imaging should lead to better dose specification in radiotherapy treatment planning; however, photon scatter and down-scatter from the 245- to the 171-keV photopeak represent significant challenges for quantitative SPECT. We have extended to /sup 111/In a general-spectral (GS) scatter-compensation method. List-mode acquisitions of a 1.6-cm-diam. sphere containing /sup 111/In were obtained with the sphere in three different locations on the major axis of a water-filled elliptical cylinder. The sphere was then removed, the phantom was injected with /sup 111/In, repositioned, and scanned repeatedly. High-count, list-mode data from separate sphere and background scans were rebinned into 10-keV windows from 100-280 keV. Attenuated projections, free of scatter and noise, were simulated for use in a least-squares procedure to optimize GS coefficients for a sphere activity-estimation task. Scattered photons in both photopeaks were estimated separately from synthetic noisy projections under different conditions of activity contrast and sphere location; projections were reconstructed with our joint, multi-energy OSEM program. The bias of sphere activity values estimated from projections was less than 7% for both photopeaks and for all contrast values ranging from 2:1 to 8:1; the bias (precision) of sphere activity estimated from OSEM reconstructions was less than 8.5% (3%) for all sphere positions. The GS compensation method is a promising approach for quantitative /sup 111/In SPECT.
Starting Page	3682
Ending Page	3684
File Size	721342
Page Count	3
File Format	PDF
ISBN	0780387007
ISSN	10823654
e-ISBN	0780387015
DOI	10.1109/NSSMIC.2004.1466680
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-10-16
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electromagnetic scattering Particle scattering Single photon emission computed tomography Imaging phantoms X-ray scattering Image reconstruction Attenuation Contamination Optimization methods Collimators
Content Type	Text
Resource Type	Article

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