NDLI: Compact, Seamless Integration of Active Dosing and Actuation with Microneedles for Transdermal Drug Delivery

Content Provider	IEEE Xplore Digital Library
Author	Roxhed, N. Samel, B. Nordquistt, L. Griss, P. Stemme, G.
Copyright Year	2006
Description	Author affiliation: Microsystem Technology Lab, School of Electrical Engineering, Royal Institute of Technology, Stockholm, Sweden (Roxhed, N.)
Abstract	This paper presents the seamless integration of a dosing and actuation unit capable of controlled release of liquid in the microliter range at very low flow-rates (, ul/h) with painless, hollow microneedles for transdermal liquid delivery. This novel system was tested in-vivo on human and rat skin and allows the detailed study of liquid uptake in biological tissue. Experiments with infusion of radioactive marker into rat shows that the actively infused liquid was successfully delivered trough the skin layer and absorbed by the circulatory system. It was also noted that, for the given way of device attachment, the amount of liquid that can be absorbed by the skin tissue is limited to a few ul/h. The presented device represents the first step towards a transdermal patch allowing for applications where very precise amounts of liquid need to be delivered into the skin (e.g. insulin). The novelty of this work is the significant step from non-integrated modules earlier presented by our and other groups into a complete microsystem.
Starting Page	414
Ending Page	417
File Size	4789695
Page Count	4
File Format	PDF
ISBN	0780394755
ISSN	10846999
DOI	10.1109/MEMSYS.2006.1627824
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-01-22
Publisher Place	Turkey
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drug delivery Skin Needles Pharmaceutical technology Pumps Reservoirs Insulin Actuators Etching Physiology
Content Type	Text
Resource Type	Article
Subject	Condensed Matter Physics Electronic, Optical and Magnetic Materials Mechanical Engineering Electrical and Electronic Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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