NDLI: Transdermal drug delivery: Microfabrication insights

Content Provider	IEEE Xplore Digital Library
Author	Iliescu, C. Bangtao Chen Jiashen Wei Zhilian Yue
Copyright Year	2009
Description	Author affiliation: Institute of Bioengineering and Nanotechnology 31 Biopolis Way, The Nanos, #04-01, Singapore 138669 (Iliescu, C.; Bangtao Chen; Jiashen Wei; Zhilian Yue)
Abstract	The paper presented an enhancement solution for transdermal drug delivery using microneedles array with biodegradable tips. The microneedles array was fabricated by using deep reactive ion etching (DRIE) and the biodegradable tips were made to be porous by electrochemical etching process. The porous silicon microneedle tips can greatly enhance the transdermal drug delivery in a minimum invasion, painless, and convenient manner, at the same time; they are breakable and biodegradable. Basically, the main problem of the silicon microneedles consists of broken microneedles tips during the insertion. The solution proposed is to fabricate the microneedle tip from a biodegradable material - porous silicon. The silicon microneedles are fabricated using DRIE notching effect of reflected charges on mask. The process overcomes the difficulty in the undercut control of the tips during the classical isotropic silicon etching process. When the silicon tips were formed, the porous tips were then generated using a classical electrochemical anodization process in MeCN/HF/HO solution. The paper presents the experimental results of in vitro release of calcein and BSA with animal skins using a microneedle array with biodegradable tips. Compared to the transdermal drug delivery without any enhancer, the microneedle array had presented significant enhancement of drug release.
Starting Page	203
Ending Page	209
File Size	976883
Page Count	7
File Format	PDF
ISBN	9781424444137
ISSN	1545827X
DOI	10.1109/SMICND.2009.5336568
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-10-12
Publisher Place	romania
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drug delivery Silicon Biodegradable materials Skin Etching Needles Mesoporous materials In vitro Pain Solids transdermal delivery Microneedles biodegradable
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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