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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Ming-Cheng Shih Yu-Shih Weng Ting-Chen Shih Rung-Jinu Gau Cheng-Hsien Liu |
| Copyright Year | 2006 |
| Description | Author affiliation: Institute of MicroElectroMechanical System, National Tsing Hua University, Taiwan, R.O.C; Biomedical Engineering Center, Industrial Technology Research Institute, Taiwan, R.O.C (Ming-Cheng Shih) |
| Abstract | We apply the biomimetic engineering concept to design a microfluidic device which mimics the flow field of the real functional liver tissue. HepG2/C3A in microreactor not only possessed the ultrastructure of tight junctions and apical microvilli, but also arranged as hepatic cord-like morphology under designed fluids field. In addition, albumin synthesis and urea production were also enhanced in microreactors compared to those in conventional Petri dish cultures. The microfluid cell culture array could potentially be applied in a wide range such as high throughput cell-based screening, drug screening, personal cell therapy and quantitative cell biology. |
| Starting Page | 458 |
| Ending Page | 461 |
| File Size | 453757 |
| Page Count | 4 |
| File Format | |
| ISBN | 0780394755 |
| ISSN | 10846999 |
| DOI | 10.1109/MEMSYS.2006.1627835 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2006-01-22 |
| Publisher Place | Turkey |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Inductors In vitro Cells (biology) Biomimetics Maintenance engineering Design engineering Microfluidics Liver Morphology Production |
| Content Type | Text |
| Resource Type | Article |
| Subject | Condensed Matter Physics Electronic, Optical and Magnetic Materials Mechanical Engineering Electrical and Electronic Engineering |
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