NDLI: Automatic mask generation using independent component analysis in dynamic contrast enhanced-MRI

Content Provider	IEEE Xplore Digital Library
Author	Mehrabian, H. Pang, I. Chandrana, C. Chopra, R. Martel, A.L.
Copyright Year	2011
Description	Author affiliation: Department of Medical Biophysics, University of Toronto, ON, Canada (Mehrabian, H.; Pang, I.; Chandrana, C.; Chopra, R.; Martel, A.L.)
Abstract	Studying image intensity change in each pixel in dynamic contrast enhanced (DCE)-MRI data enables differentiation of different tissue types based on their difference in contrast uptake. Pharmacokinetic modeling of tissues is commonly used to extract physiological parameters (i.e. $K^{trans}$ and ve) from the intensity-time curves. In a two compartmental model the intensity-time curve of the feeding blood vessels or arterial input function (AIF) as well as the signal from extravascular space (ES) is required. As direct measurement of these quantities is not possible some assumptions are made to approximate their values. Any error in measuring these quantities results in an error in the measured physiological parameters. We propose using Independent component analysis (ICA) to generate an automatic mask for separating the two spaces and extracting their intensity-time curves. An experimental phantom is constructed to mimic the behavior of real tissues and the actual intensity-time curves for the AIF and ES are measured from its DCE-MRI images. Then ICA is applied to the DCE dataset to separate these spaces. The result show high degree of agreement between the actual and ICA results.
Starting Page	1657
Ending Page	1661
File Size	580417
Page Count	5
File Format	PDF
ISBN	9781424441273
ISSN	19457928
DOI	10.1109/ISBI.2011.5872722
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-03-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Signal resolution Electron tubes Tumors Integrated circuits Magnetic resonance imaging Image resolution Dynamic Contrast Enhanced-MRI Independent Component Analysis Pharmacokinetic modeling
Content Type	Text
Resource Type	Article

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