NDLI: Fluorescence-enhanced optical tomography with a radiative transfer-based model

Content Provider	IEEE Xplore Digital Library
Author	Yujie Lu Sevick-Muraca, E.M.
Copyright Year	2011
Description	Author affiliation: Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 1825 Pressler Street, 77030, USA (Yujie Lu; Sevick-Muraca, E.M.)
Abstract	Time-dependent measurements of light propagation have been demonstrated to provide more information compared to time- independent, or continuous wave (CW) measurements for image reconstruction, when employing absorption or fluorescence contrast. Time-dependent measurements made in the frequency domain have been experimentally made with good signal-to-noise ratio (SNR) in preclinical and clinical research at modulation frequencies of 100MHz or less. However, measurements of higher modulation frequencies have potential to improve the reconstruction quality, if SNR can be conserved. In addition, the diffusion approximation (DA) has been demonstrated in both time dependent and independent measurements to be inaccurate in small tissue volumes as well as under conditions of high absorption and low scattering. In this paper, we proposed the third-order simplified spherical harmonics approximations (SP3)-based reconstruction algorithm for fluorescence enhanced optical tomography (FEOT) made in the frequency domain for enhanced accuracy at high modulation frequencies. In this algorithm, fully parallel implementation significantly improves the reconstruction speed and makes the large-scale data-based reconstruction possible. With the Monte Carlo-based synthetic data on the digital mouse phantom, the reconstructed results show the advantages of the proposed algorithm compared to DA-based reconstruction method.
Starting Page	484
Ending Page	487
File Size	504944
Page Count	4
File Format	PDF
ISBN	9781424441273
ISSN	19457928
DOI	10.1109/ISBI.2011.5872450
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-03-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Image reconstruction Frequency modulation Frequency domain analysis Reconstruction algorithms Photonics Monte Carlo methods Fluorescence-enhanced optical tomography reconstruction algorithm high frequency information finite element methods parallel computation
Content Type	Text
Resource Type	Article

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