NDLI: A novel shape-based diagnostic approach for early diagnosis of lung nodules

Content Provider	IEEE Xplore Digital Library
Author	El-Baz, A. Nitzken, M. Vanbogaert, E. Gimel'farb, G. Falk, R. Abo El-Ghar, M.
Copyright Year	2011
Description	Author affiliation: Medical Imaging Division, Department of Radiology, Jewish Hospital, Louisville, KY, USA (Falk, R.) \|\| Department of Computer Science, University of Auckland, New Zealand (Gimel'farb, G.) \|\| Urology and Nephrology Department, University of Mansoura, Egypt (Abo El-Ghar, M.) \|\| BioImaging Laboratory, Bioengineering Department,University of Louisville, KY, USA (El-Baz, A.; Nitzken, M.; Vanbogaert, E.)
Abstract	An alternative method of diagnosing malignant lung nodules by their shape rather than conventional growth rate is proposed. The 3D surfaces of the detected lung nodules are delineated by spherical harmonic analysis that represents a 3D surface of the lung nodule supported by the unit sphere with a linear combination of special basis functions, called spherical harmonics (SHs). The proposed 3D shape analysis is carried out in five steps: (i) 3D lung nodule segmentation with a deformable 3D boundary controlled by two probabilistic visual appearance models (the learned prior and the estimated current appearance one); (ii) 3D Delaunay triangulation to construct a 3D mesh model of the segmented lung nodule surface; (iii) mapping this model to the unit sphere; (iv) computing the SHs for the surface; and (v) determining the number of the SHs to delineate the lung nodule. We describe the lung nodule shape complexity with a new shape index, the estimated number of the SHs, and use it for the K-nearest classification into malignant and benign lung nodules. Preliminary experiments on 109 lung nodules (51 malignant and 58 benign) resulted in the 94.4% correct classification (for the 95% confidence interval), showing the proposed method is a promising supplement to current technologies for the early diagnosis of lung cancer.
Starting Page	137
Ending Page	140
File Size	682797
Page Count	4
File Format	PDF
ISBN	9781424441273
ISSN	19457928
DOI	10.1109/ISBI.2011.5872373
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-03-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Variable speed drives Indexes Physics Face spherical harmonics Lung nodules shape analysis
Content Type	Text
Resource Type	Article

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