NDLI: Tracking C. elegans swimming for high-throughput phenotyping

Content Provider	IEEE Xplore Digital Library
Author	Restif, C. Ibanez-Ventoso, C. Driscoll, M. Metaxas, D.
Copyright Year	2011
Description	Author affiliation: Center for Computational Biomedicine Imaging and Modeling, Rutgers, New Jersey, USA (Restif, C.; Metaxas, D.) \|\| Department of Molecular Biology and Biochemistry, Rutgers, New Jersey, USA (Ibanez-Ventoso, C.; Driscoll, M.)
Abstract	The model organism C. elegans is widely used for phenotype studies, where the behaviors of large numbers of individuals have to be measured accurately. Swimming motions exhibit unique aspects of their behavior, but are significantly more difficult to track than crawling motions. Filming multiple worms is necessary for high-throughput phenotype experiments, but adds to the complexity of tracking. Here we present a novel method to segment and track multiple swimming worms. Segmentation is done by low-level-vision processing followed by articulated model fitting. Tracking is performed by iteratively adjusting the articulated models to the successive frames. We tested our method on 404 videos and 2020 worms, and report results of 94.1% of worms tracked, which are valid 92.1% of the time. The models we use enable a cheap computation of a variety of measures of behavior. We report a quantitative comparison of three mutants using existing and novel phenotype measures, showing statistically significant differences of behavior.
Starting Page	1542
Ending Page	1548
File Size	1078884
Page Count	7
File Format	PDF
ISBN	9781424441273
ISSN	19457928
DOI	10.1109/ISBI.2011.5872695
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-03-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Grippers Videos Pixel Computational modeling Tracking Extremities Image segmentation Phenotyping Segmentation C. elegans Articulated model
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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