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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Lebenberg, J. Herard, A.-S. Dubois, A. Dhenain, M. Hantraye, P. Frouin, V. Delzescaux, T. |
| Copyright Year | 2009 |
| Description | Author affiliation: SCSR, CEA-DSV-I2BM, Evry, France (Frouin, V.) || MIRCen-LMN-CNRS-URA 2210, CEA-DSV-I2BM, Fontenay-aux-Roses, France (Lebenberg, J.; Herard, A.-S.; Dubois, A.; Dhenain, M.; Hantraye, P.; Delzescaux, T.) |
| Abstract | Many analyses in neurosciences are carried out on histological and autoradiographic datasets and performed by manually drawing regions of interest on these 2D post mortem data. Such task being time-consuming, we propose an automated segmentation strategy to analyze 3D post mortem brain images. This method is based on the co-registration of a MRI-based 3D digital atlas on 3D-reconstructed post mortem data. We first deformed the original MRI on post mortem volumes. We then applied deformation parameters to warp the digital atlas. The method was tested on APP/PS1 mouse models of Alzheimer's disease and PS1 control littermates. Its reliability was qualitatively evaluated and a quantitative assessment was performed by comparing atlas and manual segmentations. Our results show this approach is promising to investigate at organ scale post mortem mouse datasets faster and in a more robust manner than with classical methods. |
| Starting Page | 1182 |
| Ending Page | 1185 |
| File Size | 510215 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781424439317 |
| ISSN | 19457928 |
| DOI | 10.1109/ISBI.2009.5193269 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2009-06-28 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Mice Performance analysis Image segmentation Image analysis Brain Magnetic resonance imaging Testing Alzheimer's disease Performance evaluation Robustness Mouse brain atlas Biological image processing Image registration Image region analysis |
| Content Type | Text |
| Resource Type | Article |
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