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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Peroni, M. Spadea, M.F. Riboldi, M. Baroni, G. Chen, G.T.Y. Sharp, G.C. |
| Copyright Year | 2009 |
| Description | Author affiliation: Department of Bioengineering, Politecnico di Milano University, Italy (Peroni, M.; Spadea, M.F.; Riboldi, M.; Baroni, G.) || Department of Radiation Oncology, Massachusetts General Hospital, Boston, USA (Chen, G.T.Y.; Sharp, G.C.) |
| Abstract | The objective of this work is to validate a fast and reliable 4D-based adaptive treatment planning procedure for the Radiation Oncology clinic. A non-rigid B-Spline based registration is performed between CT scans at different respiratory phases. Radiotherapy contours drawn on a reference phase are than propagated to the target phase. We present results from two novel validation methods: a validation study using a 4D anthropomorphic computational phantom, and a patient data analysis comparing auto-rater versus inter-rater variability. For the phantom study, the overlap was greater than 90%, while the diameter variation was 5.1% at exhale and 3.4% at inhale. For the patient dataset, pairwise auto-rater Dice coefficient values exceeded inter-rater values for 9 of 15 structures. Though subject to inaccuracies caused by residual motion artifacts, and manual contouring variations, the reliability of the method suggests it could be soon introduced in the clinical practice. |
| Starting Page | 1071 |
| Ending Page | 1074 |
| File Size | 289625 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781424439317 |
| ISSN | 19457928 |
| DOI | 10.1109/ISBI.2009.5193241 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2009-06-28 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Lungs Cancer Biomedical applications of radiation Imaging phantoms Lesions Oncology Medical treatment Spline Computed tomography Anthropomorphism Re-planning Contour Propagation Deformable Registration Adaptive Radiation Therapy 4D Treatment Planning |
| Content Type | Text |
| Resource Type | Article |
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