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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Zhexing Liu Hongtu Zhu Marks, B.L. Katz, L.M. Goodlett, C.B. Gerig, G. Styner, M. |
| Copyright Year | 2009 |
| Description | Author affiliation: Neuro Image Research and Analysis Laboratories, University of North Carolina at Chapel Hill, United States (Zhexing Liu; Styner, M.) || Depts. of Biostatistics, University of North Carolina at Chapel Hill, United States (Hongtu Zhu) || Depts. of Exercise and Sport Science, University of North Carolina at Chapel Hill, United States (Marks, B.L.; Katz, L.M.) || Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, United States (Goodlett, C.B.; Gerig, G.) |
| Abstract | Diffusion tensor MRI (DTI) is now a widely used modality to investigate the fiber tissues in vivo, especially the white matter in brain. An automatic pipeline is described in this paper to conduct a localized voxel-wise multiple-subject group comparison study of DTI. The pipeline consists of 3 steps: 1) Preprocessing, including image format converting, image quality check, eddy-current and motion artifact correction, skull stripping and tensor image estimation, 2) study-specific unbiased DTI atlas computation via affine followed by fluid nonlinear registration and warping of all individual DTI images into the common atlas space to achieve voxel-wise correspondence, 3) voxel-wise statistical analysis via heterogeneous linear regression and wild bootstrap technique for correcting for multiple comparisons. This pipeline was applied to process data from a fitness and aging study and preliminary results are presented. The results show that this fully automatic pipeline is suitable for voxel-wise group DTI analysis. |
| Starting Page | 807 |
| Ending Page | 810 |
| File Size | 344582 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781424439317 |
| ISSN | 19457928 |
| DOI | 10.1109/ISBI.2009.5193172 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2009-06-28 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Diffusion tensor imaging Pipelines Tensile stress Magnetic resonance imaging In vivo Image converters Image quality Motion analysis Skull Motion estimation Group comparison Diffusion tensor MRI Voxel-wise analysis |
| Content Type | Text |
| Resource Type | Article |
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