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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Xinyang Liu Yonggang Shi Morra, J. Liu Xiuwen Thompson, P. Mio, W. |
| Copyright Year | 2009 |
| Description | Author affiliation: Laboratory of NeuroImaging, UCLA School of Medicine, Los Angeles, CA 90095, USA (Yonggang Shi; Morra, J.; Thompson, P.) || Department of Computer Science, Florida State University, Tallahasse, 32306, USA (Liu Xiuwen) || Department of Mathematics, Florida State University, Tallahasse, 32306, USA (Xinyang Liu; Mio, W.) |
| Abstract | We construct a multi-scale model of shape of surfaces in 3D space based on the heat kernel associated with the Laplace-Beltrami operator. The model is applied to the analysis of longitudinal neuroimaging data collected by the Alzheimer's Disease Neuroimaging Initiative. We use measures of shape deformation energy to quantify, compare and create maps of regional changes in hippocampal shape in normal aging, progression of Alzheimer's disease and mild cognitive impairment over a one-year period. |
| Starting Page | 879 |
| Ending Page | 882 |
| File Size | 467734 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781424439317 |
| ISSN | 19457928 |
| DOI | 10.1109/ISBI.2009.5193193 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2009-06-28 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Atrophy Shape measurement Space heating Alzheimer's disease Neuroimaging Kernel Hippocampus Aging Mathematical model Mathematics ADNI Shape space heat kernel hippocampal atrophy |
| Content Type | Text |
| Resource Type | Article |
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