NDLI: Relations Between the Timing of the Second Heart Sound and Aortic Blood Pressure

Content Provider	IEEE Xplore Digital Library
Author	Xin-Yu Zhang MacPherson, E. Yuan-Ting Zhang
Copyright Year	1964
Abstract	The second heart sound (S2) is triggered by an aortic valve closure as a result of the ventricular-arterial interaction of the cardiovascular system. The objective of this paper is to investigate the timing of S2 in response to the changes in hemodynamic parameters and its relation to aortic blood pressure (BP). An improved model of the left ventricular-arterial interaction was proposed based on the combination of the newly established pressure source model of the ventricle and the nonlinear pressure-dependent compliance model of the arterial system. The time delay from the onset of left ventricular pressure rise to the onset of S2 (RS₂) was used to measure the timing of S2. The results revealed that RS₂ bears a strong negative correlation with both systolic blood pressure and diastolic blood pressure under the effect of changing peripheral resistance, heart rate, and contractility. The results were further validated by a series of measurements of 16 normal subjects submitted to dynamic exercise. This study helps understand the relationship between the timing of S2 and aortic BP under various physiological and pathological conditions.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	7
File Size	897970
Starting Page	1291
Ending Page	1297
File Format	PDF
ISSN	00189294
Volume Number	55
Issue Number	4
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-04-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Timing Blood pressure Electrical resistance measurement Heart valves Cardiovascular system Hemodynamics Delay effects Pressure measurement Time measurement Heart rate model simulation Cardiovascular modeling heart-arterial interaction heart sounds
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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