NDLI: Numerical Design of Experiment for Sensitivity Analysis—Application to Skin Burn Injury Prediction

Content Provider	IEEE Xplore Digital Library
Author	Autrique, L. Lormel, C.
Copyright Year	1964
Abstract	Temperature evolution and skin burn process resulting from a laser radiation exposure are investigated in this paper. Transient temperature in skin is numerically estimated using a 1-D multilayered model based on Penne's equation. The degree of burn injury is numerically evaluated by using an Arrhenius-type function. Unfortunately, most of the mathematical model parameters are not well defined in literature. Thus, a sensitivity analysis has been performed in order to evaluate the effect of each parameters inaccuracy on temperature estimation and on burn injuries prediction (according to several authors' characterization). Investigated parameters uncertainties that crucially invalidate the thermal model are as follows: epidermis and dermis volumetric heat, extinction coefficient, and skin thickness of the affected area. Considering the damage prediction, the activation energy is a key parameter for the validation of an efficient predictive tool.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	12
File Size	833197
Starting Page	1279
Ending Page	1290
File Format	PDF
ISSN	00189294
Volume Number	55
Issue Number	4
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-04-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Skin Injuries Temperature sensors Laser modes Equations Mathematical model Sensitivity analysis Performance evaluation Uncertain systems Epidermis sensitivity analysis Biological thermal factors burn prediction mathematical model nonlinear system
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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