NDLI: Opposing roles for complement component C5a in tumor progression and the tumor microenvironment.

Please wait, while we are loading the content...

Year: 2017 Volume: 198

Year: 2016 Volume: 197

Year: 2016 Volume: 196

Year: 2015 Volume: 195

Year: 2015 Volume: 194

Year: 2014 Volume: 193

Year: 2014 Volume: 192

Year: 2013 Volume: 191

Year: 2013 Volume: 190

Year: 2012 Volume: 189

Year: 2012 Volume: 189 Issue: 12

Year: 2012 Volume: 189 Issue: 11

Year: 2012 Volume: 189 Issue: 10

Year: 2012 Volume: 189 Issue: 9

Year: 2012 Volume: 189 Issue: 8

Year: 2012 Volume: 189 Issue: 7

Year: 2012 Volume: 189 Issue: 6

Tissue-expressed B7x affects the immune response to and outcome of lethal pulmonary infection.

The development and function of memory regulatory T cells after acute viral infections.

Shaping of human germline IgH repertoires revealed by deep sequencing.

Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon.

IL-10 acts as a developmental switch guiding monocyte differentiation to macrophages during a murine peritoneal infection.

IFN-Î³ production by allogeneic Foxp3+ regulatory T cells is essential for preventing experimental graft-versus-host disease.

The chemokine receptors CXCR1 and CXCR2 couple to distinct G protein-coupled receptor kinases to mediate and regulate leukocyte functions.

Role of Mincle in alveolar macrophage-dependent innate immunity against mycobacterial infections in mice.

Stabilization of HIF-2α induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth in a murine melanoma $model^{}$

Expansion of effector memory regulatory T cells represents a novel prognostic factor in lower risk myelodysplastic syndrome.

Novel humanized and highly efficient bispecific antibodies mediate killing of prostate stem cell antigen-expressing tumor cells by CD8+ and CD4+ T cells.

Globosides but not isoglobosides can impact the development of invariant NKT cells and their interaction with dendritic cells.

Host factor transcriptional regulation contributes to preferential expression of HIV type 1 in IL-4-producing CD4 T cells.

Enhanced Tim3 Activity Improves Survival After Influenza $Infection^{}$

Cutting edge: generation of memory precursors and functional memory CD8+ T cells depends on T cell factor-1 and lymphoid enhancer-binding factor-1.

Myelin basic protein-specific TCR/HLA-DRB5*01:01 transgenic mice support the etiologic role of DRB5*01:01 in multiple sclerosis.

Cutting edge: a novel mechanism bridging innate and adaptive immunity: IL-12 induction of CD25 to form high-affinity IL-2 receptors on NK cells.

Lung T lymphocyte trafficking and activation during ischemic acute kidney injury.

Genetically driven target tissue overexpression of CD40: a novel mechanism in autoimmune disease.

Natural IgM mediates complement-dependent uptake of Francisella tularensis by human neutrophils via complement receptors 1 and 3 in nonimmune serum.

Protective role of commensals against Clostridium difficile infection via an IL-1ß-mediated positive-feedback loop.

Upstream stimulating factors regulate the expression of RORÎ³T in human lymphocytes.

Shp2 plays an important role in acute cigarette smoke-mediated lung inflammation.

Microbial carriage state of peripheral blood dendritic cells (DCs) in chronic periodontitis influences DC differentiation, atherogenic potential.

Vesicles released by activated T cells induce both Fas-mediated RIP-dependent apoptotic and Fas-independent nonapoptotic cell deaths.

Type III IFNs are produced by and stimulate human plasmacytoid dendritic cells.

Identification of pancreatic glycoprotein 2 as an endogenous immunomodulator of innate and adaptive immune responses.

MyD88 drives the IFN-ß response to Lactobacillus acidophilus in dendritic cells through a mechanism involving IRF1, IRF3, and IRF7.

Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-ß1/Smad6 signaling.

Tryptophan depletion and the kinase GCN2 mediate IFN-Î³-induced autophagy.

Cutting edge: intravascular staining redefines lung CD8 T cell responses.

Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells.

Trefoil factor 2 negatively regulates type 1 immunity against Toxoplasma gondii.

Immune mechanism of the antitumor effects generated by bortezomib.

The adaptor 3BP2 is required for early and late events in FcÎµRI signaling in human mast cells.

Cutting edge: TLR13 is a receptor for bacterial RNA.

CD28 promotes CD4+ T cell clonal expansion during infection independently of its YMNM and PYAP motifs.

The Ifng gene is essential for Vdr gene expression and vitamin D3-mediated reduction of the pathogenic T cell burden in the central nervous system in experimental autoimmune encephalomyelitis, a multiple sclerosis model.

Cyclin-dependent kinase inhibitor Cdkn2c deficiency promotes B1a cell expansion and autoimmunity in a mouse model of lupus.

Cutting edge: 4-1BB controls regulatory activity in dendritic cells through promoting optimal expression of retinal dehydrogenase.

CD5-dependent CK2 activation pathway regulates threshold for T-cell $anergy^{}$

Retention of Anergy and Inhibition of Antibody Responses During Acute Gammaherpesvirus 68 $Infection^{}$

The Akt1 isoform is required for optimal IFN-ß transcription through direct phosphorylation of ß-catenin.

Molecular and immunological characterization of Tri a 36, a low molecular weight glutenin, as a novel major wheat food allergen.

TIPE2 controls innate immunity to RNA by targeting the phosphatidylinositol 3-kinase-Rac pathway.

Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses.

Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models.

Adiponectin regulates cutaneous wound healing by promoting keratinocyte proliferation and migration via the ERK signaling pathway.

Tc17 CD8+ T cells potentiate Th1-mediated autoimmune diabetes in a mouse model.

Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback.

Immune surveillance properties of human NK cell-derived exosomes.

Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells.

Caveolin-1-mediated negative signaling plays a critical role in the induction of regulatory dendritic cells by DNA and protein coimmunization.

Chemical chaperones curcumin and 4-phenylbutyric acid improve secretion of mutant factor H R127H by fibroblasts from a factor H-deficient patient.

Early secreted antigenic target of 6-kDa protein of Mycobacterium tuberculosis primes dendritic cells to stimulate Th17 and inhibit Th1 immune responses.

Autoantigen recognition is required for recruitment of IGRP(206-214)-autoreactive CD8+ T cells but is dispensable for tolerance.

CD28-B7 interaction modulates short- and long-lived plasma cell function.

FcÎ³ receptors inhibit mouse and human basophil activation.

ICOS-expressing CD4 T cells induced via TLR4 in the nasal mucosa are capable of inhibiting experimental allergic asthma.

Opposing roles for complement component C5a in tumor progression and the tumor microenvironment.

Neutrophil extracellular traps: double-edged swords of innate immunity.

Year: 2012 Volume: 189 Issue: 5

Year: 2012 Volume: 189 Issue: 4

Year: 2012 Volume: 189 Issue: 3

Year: 2012 Volume: 189 Issue: 2

Year: 2012 Volume: 189 Issue: 1

Year: 2012 Volume: 188

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

Opposing roles for complement component C5a in tumor progression and the tumor microenvironment.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gunn, Lacey Hu, Xiaoling Ding, Chuanlin Cai, Yihua Zhang, Huang-Ge Ma, Yunfeng Aggarwal, Deep Qi, Chunjian Liu, Min Yan, Jun
Description	Country affiliation: United States Author Affiliation: Gunn L ( Division of Hematology/Oncology, Department of Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.)
Abstract	Promoting complement (C) activation may enhance immunological mechanisms of anti-tumor Abs for tumor destruction. However, C activation components, such as C5a, trigger inflammation, which can promote tumor growth. We addressed the role of C5a on tumor growth by transfecting both human carcinoma and murine lymphoma with mouse C5a. In vitro growth kinetics of C5a, control vector, or parental cells revealed no significant differences. Tumor-bearing mice with C5a-transfected xenografted tumor cells had significantly less tumor burden as compared with control vector tumors. NK cells and macrophages infiltrated C5a-expressing tumors with significantly greater frequency, whereas vascular endothelial growth factor, arginase, and TNF- production were significantly less. Tumor-bearing mice with high C5a-producing syngeneic lymphoma cells had significantly accelerated tumor progression with more Gr-1+CD11b+ myeloid cells in the spleen and overall decreased CD4+ and CD8+ T cells in the tumor, tumor-draining lymph nodes, and the spleen. In contrast, tumor-bearing mice with low C5a-producing lymphoma cells had a significantly reduced tumor burden with increased IFN-Î³-producing CD4+ and CD8+ T cells in the spleen and tumor-draining lymph nodes. These studies suggest concentration of local C5a within the tumor microenvironment is critical in determining its role in tumor progression.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1200846
Journal	The Journal of Immunology
Issue Number	6
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-09-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Complement C5a Physiology Lymphoma Immunology Pathology Ovarian Neoplasms Tumor Microenvironment Animals Carcinoma Genetics Cell Line, Tumor Cell Movement Coculture Techniques Secretion Disease Progression Immunity, Innate Leukocytes Metabolism Mice Mice, Scid Mice, Transgenic Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in