NDLI: Identification of pancreatic glycoprotein 2 as an endogenous immunomodulator of innate and adaptive immune responses.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Werner, Lael Fritz, Christina Roggenbuck, Dirk Paclik, Daniela Reinhold, Dirk Sturm, Andreas
Description	Country affiliation: Germany Author Affiliation: Werner L ( Division of Hepatology and Gastroenterology, Department of Medicine, Charité-Campus Virchow Clinic, Medical University of Berlin, 13353 Berlin, Germany.)
Abstract	Pancreatic autoantibodies are Crohn disease-specific serologic markers. The function and immunological role of their recently identified autoantigen, glycoprotein 2 (GP2), are unknown. We therefore investigated the impact of GP2 on modulation of innate and adaptive immune responses to evaluate its potential therapeutic use in mucosal inflammation. Our data indicate a previously unknown function for GP2 as an immunomodulator. GP2 was ubiquitously expressed on cells vital to mucosal immune responses. The expression of GP2 was upregulated on activated human T cells, and it was further influenced by pharmaceutical TNF- inhibitors. Recombinant GP2 significantly decreased human intestinal epithelial cells, mucosal and peripheral T cell proliferation, apoptosis, and activation, and it distinctly modulated cytokine secretion. Furthermore, intestinal epithelial cells stimulated with GP2 potently attracted T cells. In conclusion, we demonstrate a novel role for GP2 in immune regulation that could provide a platform for new therapeutic interventions in the treatment of Crohn disease.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	6
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-09-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Crohn Disease Immunology Therapy Gpi-linked Proteins Physiology Immunologic Factors Adaptive Immunity Autoantigens Cell Line Cells, Cultured Colitis, Ulcerative Immunity, Innate Intestinal Mucosa Metabolism Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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