NDLI: Trefoil factor 2 negatively regulates type 1 immunity against Toxoplasma gondii.

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Trefoil factor 2 negatively regulates type 1 immunity against Toxoplasma gondii.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Egan, Charlotte E. Herbert, De'broski R. Aliberti, Julio Wu, David Mirpuri, Julie McBerry, Cortez Boon, Louis Hogan, Simon P. Denkers, Eric Y. Boespflug, Nicholas Yang, Yanfen Butcher, Barbara Rani, Reena
Description	Country affiliation: United States Author Affiliation: McBerry C ( Division of Molecular Immunology, Cincinnati Children's Research Foundation, Cincinnati, OH 45229, USA.)
Abstract	IL-12-mediated type 1 inflammation confers host protection against the parasitic protozoan Toxoplasma gondii. However, production of IFN-Î³, another type 1 inflammatory cytokine, also drives lethality from excessive injury to the intestinal epithelium. As mechanisms that restore epithelial barrier function following infection remain poorly understood, this study investigated the role of trefoil factor 2 (TFF2), a well-established regulator of mucosal tissue repair. Paradoxically, TFF2 antagonized IL-12 release from dendritic cells (DCs) and macrophages, which protected TFF2-deficient (TFF2(-/-)) mice from T. gondii pathogenesis. Dysregulated intestinal homeostasis in naive TFF2(-/-) mice correlated with increased IL-12/23p40 levels and enhanced T cell recruitment at baseline. Infected TFF2(-/-) mice displayed low rates of parasite replication and reduced gut immunopathology, whereas wild-type (WT) mice experienced disseminated infection and lethal ileitis. p38 MAPK activation and IL-12p70 production was more robust from TFF2(-/-)CD8+ DC compared with WT CD8+ DC and treatment of WT DC with rTFF2 suppressed TLR-induced IL-12/23p40 production. Neutralization of IFN-Î³ and IL-12 in TFF2(-/-) animals abrogated resistance shown by enhanced parasite replication and infection-induced morbidity. Hence, TFF2 regulated intestinal barrier function and type 1 cytokine release from myeloid phagocytes, which dictated the outcome of oral T. gondii infection in mice.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1103374
Journal	The Journal of Immunology
Issue Number	6
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-09-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Down-regulation Immunology Mucins Physiology Muscle Proteins Peptides Toxoplasma Toxoplasmosis Parasitology Animals Cytokines Antagonists & Inhibitors Secretion Disease Models, Animal Genetics Immunity, Cellular Inflammation Pathology Intestinal Mucosa Mice Mice, Inbred C57bl Mice, Knockout Deficiency Phagocytosis Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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