NDLI: Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Carbone, Fortunata Cassano, Silvana Galgani, Mario Auvinen, Petri Formisano, Luigi La Cava, Antonio Greco, Dario Qian, Kui De Rosa, Veronica Matarese, Giuseppe Stallone, Giovanni Procaccini, Claudio Calì, Gaetano
Description	Country affiliation: Italy Author Affiliation: Procaccini C ( Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli 80131, Italy.)
Abstract	The sensing by T cells of metabolic and energetic changes in the microenvironment can determine the differentiation, maturation, and activation of these cells. Although it is known that mammalian target of rapamycin (mTOR) gauges nutritonal and energetic signals in the extracellular milieu, it is not known how mTOR and metabolism influence CD4+CD25-FOXP3- effector T cell (Teff) responses. In this article, we show that leptin-induced activation of mTOR, which, in turn, controls leptin production and signaling, causes a defined cellular, biochemical, and transcriptional signature that determine the outcome of Teff responses, both in vitro and in vivo. The blockade of leptin/leptin receptor signaling, induced by genetic means or by starvation, leads to impaired mTOR activity that inhibits the proliferation of Teffs in vivo. Notably, the transcriptional signature of Teffs in the presence of leptin blockade appears similar to that observed in rapamycin-treated Teffs. These results identify a novel link between nutritional status and Teff responses through the leptin-mTOR axis and define a potential target for Teff modulation in normal and pathologic conditions.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	6
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-09-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd4-positive T-lymphocytes Immunology Leptin Physiology Tor Serine-threonine Kinases Metabolism Transcriptional Activation Animals Drug Effects Pathology Cell Line Cells, Cultured Down-regulation Genetics Enzyme Activation Mice Mice, Inbred C57bl Mice, Knockout Mice, Obese Mice, Transgenic Sirolimus Pharmacology Antagonists & Inhibitors Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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