NDLI: Role of Mincle in alveolar macrophage-dependent innate immunity against mycobacterial infections in mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Steinwede, Kathrin Maus, Regina Behler, Friederike Maus, Ulrich A. Balboa, Luciana Ueberberg, Bianca Yamasaki, Sho Kirchhof, Gabriele Welte, Tobias
Description	Country affiliation: Germany Author Affiliation: Behler F ( Department of Experimental Pneumology, Hannover Medical School, Hannover 30625, Germany.)
Abstract	The role of macrophage-inducible C-type lectin Mincle in lung innate immunity against mycobacterial infection is incompletely defined. In this study, we show that wild-type (WT) mice responded with a delayed Mincle induction on resident alveolar macrophages and newly immigrating exudate macrophages to infection with Mycobacterium bovis bacillus Calmette-Guérin (BCG), peaking by days 14-21 posttreatment. As compared with WT mice, Mincle knockout (KO) mice exhibited decreased proinflammatory mediator responses and leukocyte recruitment upon M. bovis BCG challenge, and they demonstrated increased mycobacterial loads in pulmonary and extrapulmonary organ systems. Secondary mycobacterial infection on day 14 after primary BCG challenge led to increased cytokine gene expression in sorted alveolar macrophages of WT mice, but not Mincle KO mice, resulting in substantially reduced alveolar neutrophil recruitment and increased mycobacterial loads in the lungs of Mincle KO mice. Collectively, these data show that WT mice respond with a relatively late Mincle expression on lung sentinel cells to M. bovis BCG infection. Moreover, M. bovis BCG-induced upregulation of C-type lectin Mincle on professional phagocytes critically shapes antimycobacterial responses in both pulmonary and extrapulmonary organ systems of mice, which may be important for elucidating the role of Mincle in the control of mycobacterial dissemination in mice.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	6
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-09-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Immunity, Innate Lectins, C-type Physiology Macrophages, Alveolar Immunology Pathology Membrane Proteins Mycobacterium Bovis Tuberculosis Metabolism Animals Genetics Inflammation Microbiology Biosynthesis Deficiency Lung Mice Mice, Inbred C57bl Mice, Knockout Neutrophils Signal Transduction Prevention & Control Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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