NDLI: Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells.

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Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells.

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Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Matute, Juan D. Quilliam, Lawrence A. Crotzer, Victoria L. Zhao, Heng Dinauer, Mary C. Blum, Janice S. Arias, Andrés A.
Description	Country affiliation: United States Author Affiliation: Crotzer VL ( Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.)
Abstract	Phagocyte NADPH oxidase plays a key role in pathogen clearance via reactive oxygen species (ROS) production. Defects in oxidase function result in chronic granulomatous disease with hallmark recurrent microbial infections and inflammation. The oxidase's role in the adaptive immune response is not well understood. Class II presentation of cytoplasmic and exogenous Ag to CD4(+) T cells was impaired in human B cells with reduced oxidase p40(phox) subunit expression. Naturally arising mutations, which compromise p40(phox) function in a chronic granulomatous disease patient, also perturbed class II Ag presentation and intracellular ROS production. Reconstitution of patient B cells with a wild-type, but not a mutant, p40(phox) allele restored exogenous Ag presentation and intracellular ROS generation. Remarkably, class II presentation of epitopes from membrane Ag was robust in p40(phox)-deficient B cells. These studies reveal a role for NADPH oxidase and p40(phox) in skewing epitope selection and T cell recognition of self Ag.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1103080
Journal	The Journal of Immunology
Issue Number	8
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-10-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigen Presentation Immunology B-lymphocyte Subsets Metabolism Hla-dr Antigens Nadph Oxidase Physiology Genetics Enzymology Cell Line, Transformed Intracellular Fluid Lymphocyte Activation Phosphoproteins Biosynthesis Deficiency Reactive Oxygen Species Up-regulation Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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NADPH oxidase modulates MHC class II antigen presentation by B cells

Kinetic analysis of peptide loading onto HLA-DR molecules mediated by HLA-DM.

HLA-DMA polymorphisms differentially affect MHC class II peptide loading.

Class II-antigen-negative patient and mutant B-cell lines represent at least three, and probably four, distinct genetic defects defined by complementation analysis.

Myelin-reactive type B T cells and T cells specific for low-affinity MHC-binding myelin peptides escape tolerance in HLA-DR transgenic mice.

Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responses.

Endogenous Antigen Presentation of MHC Class II Epitopes through Non-Autophagic Pathways

MHC Class II Auto-Antigen Presentation is Unconventional

Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing

Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells.

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NADPH oxidase modulates MHC class II antigen presentation by B cells

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Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells.