NDLI: CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo.

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CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ma, Liang Kishore, Madhav Nourshargh, Sussan Marelli-Berg, Federica M. Mauro, Claudio Cheung, Kenneth C. P.
Description	Country affiliation: United kingdom Author Affiliation: Ma L ( Division of Medicine, Department of Immunology, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, United Kingdom.)
Abstract	The role of CD31, an Ig-like molecule expressed by leukocytes and endothelial cells (ECs), in the regulation of T lymphocyte trafficking remains contentious. Using CD31-deficient mice, we show that CD31 regulates both constitutive and inflammation-induced T cell migration in vivo. Specifically, T cell:EC interactions mediated by CD31 molecules are required for efficient localization of naive T lymphocytes to secondary lymphoid tissue and constitutive recirculation of primed T cells to nonlymphoid tissues. In inflammatory conditions, T cell:EC CD31-mediated interactions facilitate T cell recruitment to Ag-rich sites. However, endothelial CD31 also provides a gate-keeping mechanism to limit the rate of Ag-driven T cell extravasation. This event contributes to the formation of Ag-specific effector T cell infiltrates and is induced by recognition of Ag on the endothelium. In this context, CD31 engagement is required for restoring endothelial continuity, which is temporarily lost upon MHC molecule ligation by migrating cognate T cells. We propose that integrated adhesive and signaling functions of CD31 molecules exert a complex regulation of T cell trafficking, a process that is differentially adapted depending on cell-specific expression, the presence of inflammatory conditions and the molecular mechanism facilitating T cell extravasation.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1201739
Journal	The Journal of Immunology
Issue Number	8
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-10-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Cd31 Physiology T-lymphocytes Cytology Immunology Transendothelial And Transepithelial Migration Animals Administration & Dosage Genetics Cell Communication Cells, Cultured Endothelium, Vascular Metabolism Lymphoid Tissue Mice Organ Culture Techniques Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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CD31 Exhibits Multiple Roles in Regulating T Lymphocyte Trafficking In Vivo

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CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo.