NDLI: B7x in the periphery abrogates pancreas specific damage mediated by self-reactive CD8 T cells

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B7x in the periphery abrogates pancreas specific damage mediated by self-reactive CD8 T cells

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Scandiuzzi, Lisa Lee, Jun Sik Wei, Joyce Ray, Anjana Allison, James P. Lin, Juan Loke, P'ng Zang, Xingxing Yuan, Jianda Hofmeyer, Kimberly A. Abadi, Yael M. Serreze, David V.
Description	Country affiliation: United States Author Affiliation: Lee JS ( Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.)
Abstract	B7x (B7-H4 or B7S1) is the seventh member of the B7 family, and its in vivo function remains largely unknown. Despite new genetic data linking the B7x gene with autoimmune diseases, how exactly it contributes to peripheral tolerance and autoimmunity is unclear. In this study, we showed that B7x protein was not detected on APCs or T cells in both human and mice, which is unique in the B7 family. Because B7x protein is expressed in some peripheral cells such as pancreatic ß cells, we used a CD8 T cell-mediated diabetes model (AI4 ß) in which CD8 T cells recognize an endogenous self-Ag, and found that mice lacking B7x developed more severe diabetes than control AI4 ß mice. Conversely, mice overexpressing B7x in the ß cells (Rip-B7xAI4 ß) were diabetes free. Furthermore, adoptive transfer of effector AI4 ß CD8 T cells induced diabetes in control mice, but not in Rip-B7xAI4 ß mice. Mechanistic studies revealed that pathogenic effector CD8 T cells were capable of migrating to the pancreas but failed to robustly destroy tissue when encountering local B7x in Rip-B7xAI4 ß mice. Although AI4 ß CD8 T cells in Rip-B7xAI4 ß and AI4 ß mice showed similar cytotoxic function, cell death, and global gene expression profiles, these cells had greater proliferation in AI4 ß mice than in RIP-B7xAI4 ß mice. These results suggest that B7x in nonlymphoid organs prevents peripheral autoimmunity partially through inhibiting proliferation of tissue-specific CD8 T cells, and that local overexpression of B7x on pancreatic ß cells is sufficient to abolish CD8 T cell-induced diabetes.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1201241
Journal	The Journal of Immunology
Issue Number	8
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-10-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Autoantigens Blood Cd8-positive T-lymphocytes Immunology Pathology Pancreas V-set Domain-containing T-cell Activation Inhibitor 1 Animals Transplantation Diabetes Mellitus, Experimental Prevention & Control Disease Resistance Mice Mice, Inbred C57bl Mice, Knockout Mice, Transgenic Metabolism Biosynthesis Genetics Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s. Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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B7x in the periphery abrogates pancreas specific damage mediated by self-reactive CD8 T cells

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B7x in the periphery abrogates pancreas specific damage mediated by self-reactive CD8 T cells