NDLI: Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in Flt3-negative common lymphoid progenitors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Vieira, Paulo Granato, Alessandra Pereira de Sousa, Ana Kee, Barbara L. Cumano, Ana Dias, Sheila Berthault, Claire Ramond, Cyrille
Description	Country affiliation: France Author Affiliation: Pereira de Sousa A ( Institut Pasteur, Unité de Lymphopoièse, 75015 Paris, France.)
Abstract	Lineage commitment is regulated during hematopoiesis, with stepwise loss of differentiation potential ultimately resulting in lineage commitment. In this study we describe a novel population of B/NK bipotent precursors among common lymphoid progenitors in the fetal liver and the bone marrow. The absence of T cell precursor potential, both in vivo and in vitro, is due to low Notch1 expression and secondary to inhibition of E2A activity by members of the inhibitor of DNA binding (Id) protein family. Our results demonstrate a new, Id protein-dependent, molecular mechanism of Notch1 repression, operative in both fetal and adult common lymphoid progenitors, where T cell potential is selectively inhibited without affecting either the B or NK programs. This study identifies Id proteins as negative regulators of T cell specification, before B and NK commitment, and provides important insights into the transcriptional networks orchestrating hematopoiesis.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	8
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-10-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Basic Helix-loop-helix Transcription Factors Antagonists & Inhibitors Cell Differentiation Immunology Dna-binding Proteins Down-regulation Receptor, Notch1 Stem Cells T-lymphocyte Subsets Fms-like Tyrosine Kinase 3 Deficiency Animals Genetics Cell Lineage Physiology Inhibitor Of Differentiation Protein 2 Inhibitor Of Differentiation Proteins Mice Mice, Inbred C57bl Mice, Knockout Mice, Transgenic Multigene Family Biosynthesis Cytology Metabolism Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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