NDLI: Probiotic Lactobacillus rhamnosus inhibits the formation of neutrophil extracellular traps.

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Probiotic Lactobacillus rhamnosus inhibits the formation of neutrophil extracellular traps.

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Probiotic Lactobacillus rhamnosus inhibits the formation of neutrophil extracellular traps.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Vong, Linda Lorentz, Robert J. Sherman, Philip M. Assa, Amit Glogauer, Michael
Description	Country affiliation: Canada Author Affiliation: Vong L ( Cell Biology Program, Division of Gastroenterology, Hepatology, and Nutrition, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.)
Abstract	Neutrophil extracellular traps (NETs) are an essential component of the antimicrobial repertoire and represent an effective means by which neutrophils capture, contain, and kill microorganisms. However, the uncontrolled or excessive liberation of NETs also damages surrounding cells and can contribute to disease pathophysiology. Alterations in the gut microbiota, as well as the presence of local and systemic markers of inflammation, are strongly associated with the manifestation of a spectrum of intestinal disorders, including chronic inflammatory bowel disease. Although probiotics exert beneficial effects on gut homeostasis, their direct effect on neutrophils, which are abundant in the setting of intestinal inflammation, remains unclear. In this study, we investigated the effects of nonpathogenic, enteropathogenic, and probiotic bacteria on the dynamics of NET formation. Using murine bone marrow-derived neutrophils and the neutrophil-differentiated human myeloid cell line d.HL-60, we demonstrate for the first time, to our knowledge, that probiotic Lactobacillus rhamnosus strain GG inhibits both PMA- and Staphylococcus aureus-induced formation of NETs. Moreover, probiotic L. rhamnosus strain GG had potent antioxidative activity: dampening reactive oxygen species production and phagocytic capacity of the neutrophils while protecting against cell cytotoxicity. Within the milieu of the gut, this represents a novel mechanism by which probiotics can locally dampen innate immune responses and confer desensitization toward luminal Ags.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	4
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-02-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cytotoxicity, Immunologic Immunology Extracellular Matrix Lactobacillus Rhamnosus Neutrophils Probiotics Metabolism Animals Cell Line Hl-60 Cells Immunity, Innate Inflammation Prevention & Control Inflammatory Bowel Diseases Intestines Cytology Microbiology Mice Mice, Inbred C57bl Phagocytosis Administration & Dosage Reactive Oxygen Species Staphylococcus Aureus Tetradecanoylphorbol Acetate Pharmacology Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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